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. 2022 May 11;6(6):804-812.
doi: 10.1002/ags3.12578. eCollection 2022 Nov.

Significant impact of cachexia index on the outcomes after hepatic resection for colorectal liver metastases

Yoshiaki Tanji  1 , Kenei Furukawa  1 , Koichiro Haruki  1 , Tomohiko Taniai  1 , Shinji Onda  1 , Masashi Tsunematsu  1 , Yoshihiro Shirai  1 , Mitsuru Yanagaki  1 , Yosuke Igarashi  1 , Toru Ikegami  1
Affiliations

Significant impact of cachexia index on the outcomes after hepatic resection for colorectal liver metastases

Yoshiaki Tanji et al. Ann Gastroenterol Surg. .

Abstract

Introduction: The purpose of this study was to investigate the relation between preoperative cachexia index (CXI) and long-term outcomes in patients with colorectal liver metastases (CRLM) after hepatic resection.

Method: In all,118 patients who underwent hepatic resection for CRLM were analyzed retrospectively. The relationship between CXI and the long-term outcomes in patients after hepatic resection was investigated. CXI was calculated based on preoperative skeletal muscle index, serum albumin level, and neutrophil-lymphocyte ratio.

Results: The multivariate analysis showed that extrahepatic lesion (hazard ratio [HR] 2.86, 95% confidence interval [CI] 1.48-5.53, P < .01) and high CXI (HR 0.44, 95% CI 0.20-0.98, P = .04) were independent and significant predictors of disease-free survival. Moreover, extrahepatic lesion (HR 2.32, 95% CI 1.03-5.22, P = .04), high CXI (HR 0.17, 95% CI 0.05-0.57, P < .01), and curability R 1 or 2 (HR 3.29, 95% CI 1.23-8.78, P = .02) were independent and significant predictors of overall survival.

Conclusion: CXI is a useful prognostic factor for disease-free survival and overall survival after hepatic resection in CRLM patients.

Keywords: cachexia; colorectal liver metastases; liver resection.

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Figures

FIGURE 1
FIGURE 1
(A) Kaplan–Meier curve for disease‐free survival after hepatic resection for colorectal liver metastasis. (B) Kaplan–Meier curve for overall survival after hepatic resection for colorectal liver metastasis
See this image and copyright information in PMC

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