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Case Reports
. 2022 Oct 27;52(4):100-103.
doi: 10.64719/pb.4454.

Agomelatine Monotherapy for Autism-A Case Report

Ahmed Naguy  1 , Saxby Pridmore  2 , Mohammed A Jamali  3 , Alaa Eisa Hasan  4 , Bibi Alamiri  5
Affiliations
Case Reports

Agomelatine Monotherapy for Autism-A Case Report

Ahmed Naguy et al. Psychopharmacol Bull. .

Abstract

ASD is commonly associated with a host of challenging behaviours. Pharmacotherapy is indicated if psycho-social and educational interventions fail. Atypical antipsychotics have the strongest evidence-base so far, with both risperidone and aripiprazole are FDA-approved. Unfortunately, their use is fraught with metabolic and neuro-hormonal side effects. Here, authors report on a case of ASD/mild ID with behavioural dyscontrol that failed multiple psychotropic trials and ultimately responded favourably to agomelatine monotherapy. This was achieved with excellent tolerability. This might open new venues in such complicated cases.

Keywords: ASD; agomelatine; behavioral dyscontrol.

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References

    1. Naguy A, Al-Humoud AM, Pridmore S et al. Low-Dose Risperidone for an Autistic Child with Comorbid ARFID and Misophonia. Psychopharmacol Bull . 2022;52(1):91–94. - PMC - PubMed
    1. Naguy A. A Roadmap to Clinical Assessment and Evaluation of Autism Spectrum Disorder. J Family Med Prim Care . 2017;6(4):883–884. - PMC - PubMed
    1. Naguy A, Alamiri B. Successful Agomelatine Monotherapy For An Adolescent With Attention Deficit Hyperactivity Disorder And Comorbid Migraine. CNS Spectr . 2022;27(2):134–135. - PubMed
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    1. Ballester P, Martinez MJ, Javaloyes A et al. Agomelatine Effectiveness In Sleep Disturbances In Autism Spectrum Disorder. Clin Ther . 2015;37(8):Se132–e133.

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