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Review
. 2022 Oct 19:13:1013992.
doi: 10.3389/fphar.2022.1013992. eCollection 2022.

Systematic review of Lonicerae Japonicae Flos: A significant food and traditional Chinese medicine

Senwang Zheng  1 , Songtao Liu  1 , Ajiao Hou  1 , Song Wang  1 , Yexin Na  1 , Jianhua Hu  1 , Hai Jiang  1 , Liu Yang  1
Affiliations
Review

Systematic review of Lonicerae Japonicae Flos: A significant food and traditional Chinese medicine

Senwang Zheng et al. Front Pharmacol. .

Abstract

Lonicerae Japonicae Flos has been used as a tea and medicine for more than 1,500 years. It has the functions of clearing heat, detoxification, and is often used to treat carbuncle, furuncle, throat arthralgia, erysipelas, heat-toxic blood dysentery, febrile fever. This paper summarizes the botany, ethnopharmacology, chemical composition and pharmacological action of Lonicerae Japonicae Flos from 1986 to 2022, and looks forward to the future research direction of Lonicerae Japonicae Flos. At present, the components isolated from Lonicerae Japonicae Flos include essential oils, organic acids, flavonoids, iridoids, saponins and other compounds. It has the effects of anti-inflammation, anti-virus, anti-bacteria, anti-oxidation, anti-tumor, protect liver and galltesticles, hypotensive, hypolipidemic, anti-thrombosis, anti-allergy, immune regulation and so on. It is often used in clinical treatment of diarrhea, hematochezia, febrile disease, exogenous wind-heat, and cold, swelling and toxin of carbuncle, sore throat and so on. The comprehensive evaluation of the quality of Lonicerae Japonicae Flos and the understanding of multi-target network pharmacology also need to be studied. As a kind of health food with high value, LJF is worthy of further promotion and development.

Keywords: Lonicerae Japonicae Flos; botany; ethnopharmacology; pharmacology; phytochemistry; toxicology.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Lonicera japonica Thunb. and LJF.
FIGURE 2
FIGURE 2
The structures of organic acids from LJF.
FIGURE 3
FIGURE 3
The structures of flavonoids from LJF.
FIGURE 4
FIGURE 4
The structures of triterpenes and triterpenoid saponins from LJF.
FIGURE 5
FIGURE 5
The structures of iridoids LJF.
FIGURE 6
FIGURE 6
The main structures of essential oils from LJF.
See this image and copyright information in PMC

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