Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Oct 19:10:944818.
doi: 10.3389/fped.2022.944818. eCollection 2022.

High prevalence of arthralgia among infants with Chikungunya disease during the 2019 outbreak in northern region of the state of Rio de Janeiro

Patrícia Damião Gomes  1 , Rayane Figueiredo Silva Moreira Carvalho  1 , Milena Moulin Massini  1 , Rafael Hauaji Garzon  1 , Pollianny Louzada Schiavo  2 , Regina Célia de Souza Campos Fernandes  1   3 , Thaís Louvain de Souza  1
Affiliations

High prevalence of arthralgia among infants with Chikungunya disease during the 2019 outbreak in northern region of the state of Rio de Janeiro

Patrícia Damião Gomes et al. Front Pediatr. .

Abstract

Introduction: In a low-income setting with simultaneous presence of Dengue virus, Zika virus, and Chikungunya virus (CHIKV) in the same region, the difficulty of establishing a clinical diagnosis when the molecular test is not a possibility. Thus, it is important to identify signs and symptoms of Chikungunya that can be used to differentiate it from other arboviruses in children.

Methods: This is a cross-sectional study, which was developed in Rio de Janeiro State, Brazil, with the analysis of pediatric medical records regarding arboviruses. Considering that the population had already been exposed to Dengue and Zika viruses and were experiencing the first notification of the CHIKV. The ethics committee approved this research, and all those legally responsible for the children signed the consent form.

Results: In total, 159 children were seen of which 98 were suspected CHIKV cases, and 51 had their diagnosis confirmed with reagent IgM/IgG for CHIKV. The symptoms that the pediatric population with CHIKV presented most often were fever (90.2%), arthralgia (76.5%), and exanthema (62.7%) in both suspected and confirmed cases of Chikungunya. Thus, CHIKV in those children presents a clinical profile similar to those found in other studies referring to adults. Additionally, only arthralgia and a high aspartate transaminase were related to the positivity of serology for Chikungunya.

Conclusions: This study describes the signs and symptoms of CHIKV exhibited in the pediatric population with a mild and moderate presentation similar to the findings in the adult during an epidemic experienced in a population vulnerable to CHIKV.

Keywords: Chikungunya; arbovirus; arthralgia; children; infants.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

    1. Beserra F, Oliveira GM, Marques TMA, Farias L, Santos JRD, Daher EF, et al. Clinical and laboratory profiles of children with severe chikungunya infection. Rev Soc Bras Med Trop. (2019) 52:e20180232. 10.1590/0037-8682-0232-2018 - DOI - PubMed
    1. MdS Brasil. Banco de dados do Sistema Único de Saúde-DATASUS Online: Brasil; (2022). Available at: https://datasus.saude.gov.br/acesso-a-informacao/doencas-e-agravos-de-no... [cited 2022 03-12]
    1. Albuquerque IG, Marandino R, Mendonca AP, Nogueira RM, Vasconcelos PF, Guerra LR, et al. Chikungunya virus infection: report of the first case diagnosed in Rio de Janeiro, Brazil. Rev Soc Bras Med Trop. (2012) 45(1):128–9. 10.1590/S0037-86822012000100026 - DOI - PubMed
    1. Nunes MR, Faria NR, de Vasconcelos JM, Golding N, Kraemer MU, de Oliveira LF, et al. Emergence and potential for spread of chikungunya virus in Brazil. BMC Med. (2015) 13:102. 10.1186/s12916-015-0348-x - DOI - PMC - PubMed
    1. Perisse ARS, Souza-Santos R, Duarte R, Santos F, de Andrade CR, Rodrigues NCP, et al. Zika, dengue and chikungunya population prevalence in Rio de Janeiro city, Brazil, and the importance of seroprevalence studies to estimate the real number of infected individuals. PLoS One. (2020) 15(12):e0243239. 10.1371/journal.pone.0243239 - DOI - PMC - PubMed

LinkOut - more resources