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Case Reports
. 2022 Sep 30;3(11):100419.
doi: 10.1016/j.jtocrr.2022.100419. eCollection 2022 Nov.

Development of Neuropathic Arthropathy With Entrectinib: Case Report

Nicholas P Giustini  1 , Hanna Oh  2 , Keith D Eaton  3   4
Affiliations
Case Reports

Development of Neuropathic Arthropathy With Entrectinib: Case Report

Nicholas P Giustini et al. JTO Clin Res Rep. .

Abstract

TRK inhibition can lead to on-target neurologic adverse events. Two cases illustrate the development of neuropathic arthropathy as a side effect of entrectinib. After starting entrectinib, both patients developed foot pain, swelling, and sensory changes with magnetic resonance imaging revealing marrow edema. Providers should have a low threshold to investigate foot pain or gait abnormalities thoroughly with magnetic resonance imaging and referral to specialists to aid in the diagnosis of neuropathic arthropathy, with consideration to transition to an alternative agent.

Keywords: Case report; Entrectinib; NTRK; Neuropathic Charcot arthropathy.

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Figures

Figure 1
Figure 1
Sagittal view magnetic resonance images of the right foot (T1-weighted, fat-suppressed without contrast) of patient 1 revealing diffuse bone marrow edema in the ankle and hindfoot bones (white arrows), subchondral fluid collections in the body of the calcaneus (black arrow), and a joint effusion (star).
Figure 2
Figure 2
Sagittal view magnetic resonance image of the left foot (T1-weighted, fat-suppressed without contrast) of patient 2 revealing nonspecific marrow edema within the cuboid (white arrow), lateral cuneiform (black arrow), and fourth proximal metatarsal shaft (dotted arrow).
See this image and copyright information in PMC

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