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. 2022 Oct 21:13:986882.
doi: 10.3389/fneur.2022.986882. eCollection 2022.

Different observation period of exercise training in amyotrophic lateral sclerosis patients: A meta-analysis

Baohua Zhou  1 , Jiajun Wei  1 , Yanli Zhang  1 , Yue Liu  2 , Shuhui Shan  3 , Shan Ye  1 , Baohua Li  2 , Dongsheng Fan  1 , Yongmei Luo  1
Affiliations

Different observation period of exercise training in amyotrophic lateral sclerosis patients: A meta-analysis

Baohua Zhou et al. Front Neurol. .

Abstract

Objective: The purpose of this meta-analysis was to evaluate the effect of more intensive exercise training on the functional ability of patients with amyotrophic lateral sclerosis.

Methods: Randomized controlled trials on exercise training in amyotrophic lateral sclerosis patients were retrieved from PubMed, Embase, Web of Science, Cochrane Library and other databases, and meta-analysis was conducted using a fixed effect model or random effect model. Sensitivity analysis was used as a means to study heterogeneity.

Results: A total of 8 randomized controlled trials involving 330 patients with amyotrophic lateral sclerosis were included in this study. The results showed that there was statistical significance in the influence of more intensive exercise training on amyotrophic lateral sclerosis Functional Rating Scale in the short term (0-4 months) and the medium term (5-8 months) (P < 0.05). There was no significant difference in the effect of the amyotrophic lateral sclerosis Functional Rating Scale-Revised in the short term (0-4 months) or long term (9-12 months) (P ≥ 0.05). In the medium term (5-8 months), there was statistical significance (P < 0.05). There was no significant difference in Forced vital capacity (FVC%) in the short term (0-4 months) (P > 0.05).

Conclusion: More intensive exercise training may slow the decline in functional score of amyotrophic lateral sclerosis patients, and more studies should be carried out in the future to verify the effect of more intensive exercise training in patients with amyotrophic lateral sclerosis.

Keywords: amyotrophic lateral sclerosis; exercise; functional ability; meta-analysis; rehabilitation.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram outlining the search.
Figure 2
Figure 2
Risk of bias graph.
Figure 3
Figure 3
Forest plot of experimental group vs. control group. Outcome: ALSFRS.
Figure 4
Figure 4
Forest plot of experimental group vs. control group. Outcome: ALSFRS-R.
Figure 5
Figure 5
Forest plot of experimental group vs. control group. Outcome: FVC%.
See this image and copyright information in PMC

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