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. 2023 Feb;270(2):711-725.
doi: 10.1007/s00415-022-11454-8. Epub 2022 Nov 7.

Effects of physical activity and exercise interventions on Alzheimer's disease: an umbrella review of existing meta-analyses

Susana López-Ortiz  1 , Simone Lista  2   3 , Pedro L Valenzuela  4 , José Pinto-Fraga  2 , Ricardo Carmona  2   4 , Filippo Caraci  5   6 , Giuseppe Caruso  5   6 , Nicola Toschi  7   8   9 , Enzo Emanuele  10 , Audrey Gabelle  3   11 , Robert Nisticò  12   13 , Francesco Garaci  7   14 , Alejandro Lucia  15   4 , Alejandro Santos-Lozano  2   4
Affiliations

Effects of physical activity and exercise interventions on Alzheimer's disease: an umbrella review of existing meta-analyses

Susana López-Ortiz et al. J Neurol. 2023 Feb.

Abstract

Introduction: During the last decade, physical activity (PA) (or "exercise") has been identified as one of the main modifiable factors that influence the development of Alzheimer's disease (AD) pathophysiology. We performed an umbrella review to summarize the evidence on the association between PA/exercise and the risk of developing AD risk, and the effect of exercise interventions on the progression of AD.

Methods: A systematic search was performed in PubMed, SportDiscus, Cochrane Library and Web of Science (March 2022) to identify meta-analyses assessing the association between PA and the incidence of AD, and assessing the effect of exercise interventions on patients with AD.

Results: Twenty-one studies were included. The results with strongest evidence revealed the positive effects of PA on AD risk. Specifically, meeting the WHO recommendations for PA was associated with a lower risk of AD. They also revealed positive effects of exercise on cognitive function, physical performance, and functional independence.

Conclusions: There is strong evidence of a protective effect of regular PA against AD risk; however, the dose-response association remains unclear. Physical exercise seems to improve several dimensions in patients with AD, although research is warranted to elucidate the exercise characteristics that promote the greatest benefits.

Keywords: Aging; Dementia; Geriatric; Healthy aging.

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References

    1. Alty J, Farrow M, Lawler K (2020) Exercise and dementia prevention. Pract Neurol 20:234–240 - DOI
    1. Andrade A, Siqueira TC, D'Oliveira A, Dominski FH (2021) Effects of exercise in the treatment of Alzheimer's disease: an umbrella review of systematic reviews and meta-analyses. J Aging Phys Act 30:1–17
    1. Beckett MW, Ardern CI, Rotondi MA (2015) A meta-analysis of prospective studies on the role of physical activity and the prevention of Alzheimer’s disease in older adults. BMC Geriatr 15:9 - DOI
    1. Beydoun MA, Beydoun HA, Gamaldo AA, Teel A, Zonderman AB, Wang Y (2014) Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis. BMC Public Health 14:643 - DOI
    1. Cai H, Li G, Hua S, Liu Y, Chen L (2017) Effect of exercise on cognitive function in chronic disease patients: a meta-analysis and systematic review of randomized controlled trials. Clin Interv Aging 12:773–783 - DOI

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