Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2022 Dec 1;47(12):e742-e743.
doi: 10.1097/RLU.0000000000004379. Epub 2022 Sep 6.

FDG PET/CT Aiding in Early Diagnosis of Central Pontine Myelinolysis

Affiliations
Case Reports

FDG PET/CT Aiding in Early Diagnosis of Central Pontine Myelinolysis

Varun Singh Dhull et al. Clin Nucl Med. .

Abstract

We report a 70-year-old man with central pontine myelinolysis who presented in the emergency department with recent onset altered sensorium and tremors (Glasgow Coma Scale score, 13). Laboratory findings revealed hyponatremia and hypokalemia. MRI brain was unremarkable. Subsequently, patient was referred for FDG PET/CT to rule out malignancy or paraneoplastic syndrome. FDG PET revealed focal radiotracer uptake in the pons without any underlying CT abnormality consistent with central pontine myelinolysis, thus aiding in early diagnosis where conventional imaging modality was unremarkable.

PubMed Disclaimer

Conflict of interest statement

Conflicts of interest and sources of funding: none declared.

References

    1. Adams RD, Victor M, Mancall EL. Central pontine myelinolysis: a hitherto undescribed disease occurring in alcoholic and malnourished patients. AMA Arch Neurol Psychiatry . 1959;81:154–172.
    1. Alleman AM. Osmotic demyelination syndrome: central pontine myelinolysis and extrapontine myelinolysis. Semin Ultrasound CT MR . 2014;35:153–159.
    1. Bourgouin PM, Chalk C, Richardson J, et al. Subcortical white matter lesions in osmotic demyelination syndrome. AJNR Am J Neuroradiol . 1995;16:1495–1497.
    1. Hurley RA, Filley CM, Taber KH. Central pontine myelinolysis: a metabolic disorder of myelin. J Neuropsychiatry Clin Neurosci . 2011;23:369–374.
    1. King JD, Rosner MH. Osmotic demyelination syndrome. Am J Med Sci . 2010;339:561–567.

Publication types

Substances

LinkOut - more resources