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Case Reports
. 2022 Dec 1;47(12):e749-e751.
doi: 10.1097/RLU.0000000000004388. Epub 2022 Sep 28.

Brain PET Imaging of 11C-Methionine, 18F-FDG, and 18F-THK5351 in a Case of Lymphomatoid Granulomatosis

Mana Higashihara  1 , Kenji Ishibashi, Aya M Tokumaru  2 , Kenji Ishii, Atsushi Iwata  1
Affiliations
Case Reports

Brain PET Imaging of 11C-Methionine, 18F-FDG, and 18F-THK5351 in a Case of Lymphomatoid Granulomatosis

Mana Higashihara et al. Clin Nucl Med. .

Abstract

A 52-year-old woman complained of upper respiratory symptoms and subsequently developed Wallenberg syndrome. Chest CT and brain MRI revealed multiple nodular lesions in the lungs and brain. She was pathologically diagnosed with low-grade lymphomatoid granulomatosis by lung biopsy. Brain PET examinations using 11C-methionine, 18F-FDG, and 18F-THK5351 were performed. Uptake of 11C-methionine and 18F-FDG was slightly increased in some lesions, likely reflecting the degree of inflammatory cell infiltration. 18F-THK5351 uptake was significantly increased in all lesions, likely reflecting the degree of reactive astrogliosis. This case illustrates the utility of PET studies for diagnosing lymphomatoid granulomatosis and provides insight into its pathophysiology.

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Conflict of interest statement

Conflicts of interest and sources of funding: The authors declare that they have no conflicts of interest. This study was supported by Grant-in-Aid for Scientific Research (C) No. 19 K08191 from the Japan Society for the Promotion of Science (to K. Ishibashi) and Award 2020 of Tokyo Metropolitan Geriatric Hospital (to M.H.).

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References

    1. Lerdsirisuk P, Harada R, Hayakawa Y, et al. Synthesis and evaluation of 2-pyrrolopyridinylquinoline derivatives as selective tau PET tracers for the diagnosis of Alzheimer’s disease. Nucl Med Biol . 2020;93:11–18.
    1. Ng KP, Pascoal TA, Mathotaarachchi S, et al. Monoamine oxidase B inhibitor, selegiline, reduces 18 F-THK5351 uptake in the human brain. Alzheimers Res Ther . 2017;9:25.
    1. Ng KP, Therriault J, Kang MS, et al. Rasagiline, a monoamine oxidase B inhibitor, reduces in vivo [ 18 F]THK5351 uptake in progressive supranuclear palsy. Neuroimage Clin . 2019;24:102091.
    1. Ishibashi K, Kameyama M, Tago T, et al. Potential use of 18 F-THK5351 PET to identify Wallerian degeneration of the pyramidal tract caused by cerebral infarction. Clin Nucl Med . 2017;42:e523–e524.
    1. Ishibashi K, Miura Y, Hirata K, et al. 18 F-THK5351 PET can identify astrogliosis in multiple sclerosis plaques. Clin Nucl Med . 2020;45:e98–e100.

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