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. 2022 Nov 4;101(44):e30855.
doi: 10.1097/MD.0000000000030855.

Prognostic value of preoperative systemic inflammatory response as a prognostic indicator in patients with early-stage oral squamous cell carcinoma

Toshihiko Mikami  1   2 , Akinori Funayama  1 , Kanae Niimi  1 , Kenta Haga  1 , Masami Kawaharada  1 , Akihiko Nakamura  1 , Wataru Katagiri  3 , Tadaharu Kobayashi  1
Affiliations

Prognostic value of preoperative systemic inflammatory response as a prognostic indicator in patients with early-stage oral squamous cell carcinoma

Toshihiko Mikami et al. Medicine (Baltimore). .

Abstract

To determine the usefulness of lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and inflammatory response biomarker (IRB) score for predicting disease-specific survival and delayed cervical lymph node metastasis in early-stage oral squamous cell carcinoma (OSCC). We retrospectively analyzed 72 patients with early-stage OSCC. Receiver operating characteristic curve analysis was used to determine the cutoff values for LMR, NLR, and PLR. IRB score was determined as follows: high LMR, high NLR, and low PLR, which were each rated as 1. These scores were added to obtain IRB score (range: 0-3). From univariate analysis, gender, poor mode of invasion, and high IRB score were identified as significant risk factors for disease-specific survival. However, there were no independent factors for poor prognosis in multivariate analysis. On the other hand, for delayed cervical lymph node metastasis, poor mode of invasion, low LMR, high NLR, high PLR, and high IRB score were identified as significant risk factors from univariate analysis, and in multivariate analysis, poor mode of invasion and high IRB score were confirmed as independent risk factors. IRB score and mode of invasion are potentially independent risk factors for delayed cervical lymph node metastasis in early-stage OSCC.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Kaplan–Meier survival curves of disease-specific survival according to inflammatory response biomarkers. (A) Lymphocyte-to-monocyte ratio, (B) neutrophil-to-lymphocyte ratio, (C) platelet-to-lymphocyte ratio, and (D) inflammatory response biomarker score.
Figure 2.
Figure 2.
Kaplan–Meier survival curves of delayed cervical lymph node metastasis according to inflammatory response biomarkers. (A) Lymphocyte-to-monocyte ratio, (B) neutrophil-to-lymphocyte ratio, (C) platelet-to-lymphocyte ratio, and (D) inflammatory response biomarker score.
See this image and copyright information in PMC

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