Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 May:70 Suppl 2:e30080.
doi: 10.1002/pbc.30080. Epub 2022 Nov 9.

Similarities and controversies in imaging of pediatric renal tumors: A SIOP-RTSG and COG collaboration

Justine N van der Beek  1   2 , Maddy Artunduaga  3 , Jens-Peter Schenk  4 , Meryle J Eklund  5 , Ethan A Smith  6   7 , Henrique M Lederman  8 , Anne B Warwick  9 , Annemieke S Littooij  1   2 , Geetika Khanna  10
Affiliations
Review

Similarities and controversies in imaging of pediatric renal tumors: A SIOP-RTSG and COG collaboration

Justine N van der Beek et al. Pediatr Blood Cancer. 2023 May.

Abstract

Malignant renal tumors are rare in children, and Wilms tumors (WTs) are the most common subtype. Imaging plays an essential role in the diagnosis, staging, and follow-up of these patients. Initial workup for staging is mainly performed by cross-sectional imaging modalities such as computed tomography (CT) and magnetic resonance imaging (MRI). Imaging approach within the two core international groups, the Children's Oncology Group (COG, North America) and the International Society of Pediatric Oncology - Renal Tumor Study Group (SIOP-RTSG, Europe), differs. Whereas abdominal ultrasound (US) is used for the initial diagnosis of a suspected pediatric renal tumor globally, COG protocols support the use of CT or MRI for locoregional staging, contrary to the preference for MRI over CT for abdominopelvic evaluation within the SIOP-RTSG. The purpose of this manuscript is to summarize current imaging approaches, highlighting differences and similarities within these core international groups, while focusing on future innovative efforts and collaboration within the HARMONICA initiative.

Keywords: computed tomography; kidney neoplasms; magnetic resonance imaging; pediatrics; radiology; ultrasonography.

PubMed Disclaimer

References

REFERENCES

    1. Siegel D, Li J, Henley SJ, et al. Incidence rates and trends of pediatric cancer - United States, 2001-2014. Conference Abstract. Pediatr Blood Cancer. 2018;65:e27057. doi:10.1002/pbc.27057
    1. Nakata K, Colombet M, Stiller CA, Pritchard-Jones K, Steliarova-Foucher E. Incidence of childhood renal tumours: an international population-based study. Int J Cancer. 2020;147(12):3313-3327. doi:10.1002/ijc.33147
    1. van den Heuvel-Eibrink MM, Grundy P, Graf N, et al. Characteristics and survival of 750 children diagnosed with a renal tumor in the first seven months of life: a collaborative study by the SIOP/GPOH/SFOP, NWTSG, and UKCCSG Wilms tumor study groups. Pediatr Blood Cancer. 2008;50(6):1130-1134. doi:10.1002/pbc.21389
    1. Roy P, van Peer SE, de Witte MM, et al. Characteristics and outcome of children with renal tumors in the Netherlands: the first five-year's experience of national centralization. PLoS One. 2022;17(1):e0261729. doi:10.1371/journal.pone.0261729
    1. Gylys-Morin V, Hoffer FA, Kozakewich H, Shamberger RC. Wilms tumor and nephroblastomatosis: imaging characteristics at gadolinium-enhanced MR imaging. Radiology. 1993;188(2):517-521. doi:10.1148/radiology.188.2.8392214

LinkOut - more resources