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. 2022 Sep 16;45(12):3050-3053.
doi: 10.2337/dc22-0693. Online ahead of print.

Cambridge Hybrid Closed-Loop System in Very Young Children With Type 1 Diabetes Reduces Caregivers' Fear of Hypoglycemia and Improves Their Well-Being

Carine de Beaufort  1   2   3 , Ulrike Schierloh  1 , Ajay Thankamony  4 , Julia Ware  4   5 , Malgorzata E Wilinska  5 , Elke Fröhlich-Reiterer  6 , Thomas M Kapellen  7   8 , Birgit Rami-Merhar  9 , Sabine E Hofer  10 , Fiona M Campbell  11 , James Yong  11 , Laura E Bocchino  12 , Judy Sibayan  12 , Julia Lawton  13 , Stephane Roze  14 , Maria Fritsch  6 , Alena Thiele  7 , Janet M Allen  4 , Charlotte Boughton  4 , Julia K Mader  15 , Craig Kollman  12 , Roman Hovorka  4   5 , Ineke M Pit-Ten Cate  16 ; KidsAP Consortium; KidsAP Consortium
Collaborators, Affiliations

Cambridge Hybrid Closed-Loop System in Very Young Children With Type 1 Diabetes Reduces Caregivers' Fear of Hypoglycemia and Improves Their Well-Being

Carine de Beaufort et al. Diabetes Care. .

Abstract

Objective: To evaluate the impact of CamAPS FX hybrid closed-loop (HCL) automated insulin delivery in very young children with type 1 diabetes (T1D) on caregivers' well-being, fear of hypoglycemia, and sleepiness.

Research design and methods: We conducted a multinational, open-label, randomized crossover study. Children (age 1-7 years) with T1D received treatment for two 4-month periods in random order, comparing HCL with sensor augmented pump (control). At baseline and after each treatment period, caregivers were invited to complete World Health Organization-Five Well-Being Index, Hypoglycemia Fear Survey, and Epworth Sleepiness Scale questionnaires.

Results: Caregivers of 74 children (mean ± SD age 5 ± 2 years and baseline HbA1c 7.3 ± 0.7%; 42% female) participated. Results revealed significantly lower scores for hypoglycemia fear (P < 0.001) and higher scores for well-being (P < 0.001) after HCL treatment. A trend toward a reduction in sleepiness score was observed (P = 0.09).

Conclusions: Our results suggest better well-being and less hypoglycemia fear in caregivers of very young children with T1D on CamAPS FX HCL.

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