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Review
. 2022 Nov 9;14(670):eabo5409.
doi: 10.1126/scitranslmed.abo5409. Epub 2022 Nov 9.

Interleukin-2-based therapies in cancer

Miro E Raeber  1 , Dilara Sahin  1 , Onur Boyman  1   2
Affiliations
Review

Interleukin-2-based therapies in cancer

Miro E Raeber et al. Sci Transl Med. .

Abstract

Molecular insights into the mechanism of beneficial and adverse effects of interleukin-2 (IL-2) have resulted in the development of improved IL-2 formulations with IL-2 receptor bias and tissue-targeting properties. Several of these compounds are currently in clinical development and are ushering IL-2 therapy into the current era of cancer immunotherapy.

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