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Review
. 2023 Feb;51(2):207-209.
doi: 10.1124/dmd.122.000857. Epub 2022 Nov 9.

Xenobiotic Receptors, a Journey of Rewards

Wen Xie  1
Affiliations
Review

Xenobiotic Receptors, a Journey of Rewards

Wen Xie. Drug Metab Dispos. 2023 Feb.

Abstract

The xenobiotic nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) were discovered or characterized in 1998. PXR and CAR have since been defined as master regulators of xenobiotic responses through their transcriptional regulation of drug-metabolizing enzymes and transporters. This article aims to provide an overview on the discovery of PXR and CAR as xenobiotic receptors.

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