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. 2022 Nov 9;12(1):19082.
doi: 10.1038/s41598-022-23745-1.

Influence of the coiling porosity on the risk reduction of the cerebral aneurysm rupture: computational study

Armin Sheidani  1 , M Barzegar Gerdroodbary  2 , Amin Poozesh  3 , Amir Sabernaeemi  4 , Sajad Salavatidezfouli  5 , Arash Hajisharifi  5
Affiliations

Influence of the coiling porosity on the risk reduction of the cerebral aneurysm rupture: computational study

Armin Sheidani et al. Sci Rep. .

Abstract

The formation and progress of cerebral aneurysm is highly associated with hemodynamic factors and blood flow feature. In this study, comprehensive efforts are done to investigate the blood hemodynamic effects on the creation and growth of the Internal Carotid Artery. The computational fluid dynamic method is used for the visualization of the bloodstream inside the aneurysm. Transitional, non-Newtonian and incompressible conditions are considered for solving the Navier-Stokes equation to achieve the high-risk region on the aneurysm wall. OSI and WSS of the aneurysm wall are compared within different blood flow stages. The effects of blood viscosity and coiling treatment on these factors are presented in this work. Our study shows that in male patients (HCT = 0.45), changing the porosity of coiling from 0.89 with 0.79 would decreases maximum OSI up to 75% (in maximum acceleration). However, this effect is limited to about 45% for female patients (HCT = 0.35).

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
ICA aneurysm.
Figure 2
Figure 2
Transient blood flow.
Figure 3
Figure 3
Grid production.
Figure 4
Figure 4
Validation.
Figure 5
Figure 5
The variation of the WSS on the aneurysm wall in various instants.
Figure 6
Figure 6
The change of the OSI on the aneurysm wall in four instants of maximum acceleration, peak systolic, maximum deceleration and early diastole.
Figure 7
Figure 7
The comparison of the pressure distribution on the aneurysm sac in different instants.
Figure 8
Figure 8
The blood flow feature in various instants (velocity magnitude iso-surface = 0.4 m/s).
Figure 9
Figure 9
Comparison of the WSS on ICA for different coiling porosities and blood HCTs.
Figure 10
Figure 10
Max WSS (Pa) on Aneurysm in different time instants.
Figure 11
Figure 11
Comparison of the OSI on ICA for different coiling porosities and blood HCTs.
Figure 12
Figure 12
Impacts of coiling porosity and blood HCT on the maximum WSS in different stages.
Figure 13
Figure 13
The iso-value of the blood velocity (u = 0.3 m/s).
Figure 14
Figure 14
The feature of the blood stream inside aneurysm sac in different coiling porosity and blood HCTs.
Figure 15
Figure 15
Comparison of the average velocity of the blood flow into the aneurysm sac for different condition and time instants.
See this image and copyright information in PMC

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