Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Oct 24:13:904889.
doi: 10.3389/fendo.2022.904889. eCollection 2022.

Trace elements and the thyroid

Affiliations
Review

Trace elements and the thyroid

Qing Zhou et al. Front Endocrinol (Lausanne). .

Abstract

Trace elements, such as iodine and selenium (Se), are vital to human health and play an essential role in metabolism. They are also important to thyroid metabolism and function, and correlate with thyroid autoimmunity and tumors. Other minerals such as iron (Ir), lithium (Li), copper (Co), zinc (Zn), manganese (Mn), magnesium (Mg), cadmium (Cd), and molybdenum (Mo), may related to thyroid function and disease. Normal thyroid function depends on a variety of trace elements for thyroid hormone synthesis and metabolism. These trace elements interact with each other and are in a dynamic balance. However, this balance may be disturbed by the excess or deficiency of one or more elements, leading to abnormal thyroid function and the promotion of autoimmune thyroid diseases and thyroid tumors.The relationship between trace elements and thyroid disorders is still unclear, and further research is needed to clarify this issue and improve our understanding of how trace elements mediate thyroid function and metabolism. This paper systematically reviewed recently published literature on the relationship between various trace elements and thyroid function to provide a preliminary theoretical basis for future research.

Keywords: autoimmune thyroid diseases; hyperthyroidism; hypothyroidism; thyroid; trace elements.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

    1. Zaichick V, Tsyb AF, Vtyurin BM. Trace elements and thyroid cancer. Analyst (1995) 120(3):817–21. doi: 10.1039/an9952000817 - DOI - PubMed
    1. Cooper DS. Subclinical thyroid disease: consensus or conundrum? Clin Endocrinol (Oxf) (2004) 60(4):410–2. doi: 10.1111/j.1365-2265.2004.02031.x - DOI - PubMed
    1. Zimmermann MB, Boelaert K. Iodine deficiency and thyroid disorders. Lancet Diabetes Endocrinol (2015) 3(4):286–95. doi: 10.1016/S2213-8587(14)70225-6 - DOI - PubMed
    1. Laurberg P, Cerqueira C, Ovesen L, Rasmussen LB, Perrild H, Andersen S, et al. . Iodine intake as a determinant of thyroid disorders in populations. Best Pract Res Clin Endocrinol Metab (2010) 24(1):13–27. doi: 10.1016/j.beem.2009.08.013 - DOI - PubMed
    1. Liu XH, Chen GG, Vlantis AC, van Hasselt CA. Iodine mediated mechanisms and thyroid carcinoma. Crit Rev Clin Lab Sci (2009) 46(5-6):302–18. doi: 10.3109/10408360903306384 - DOI - PubMed

LinkOut - more resources