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. 2022 Oct 31;29(11):8244-8260.
doi: 10.3390/curroncol29110651.

Patient-Factors Influencing the 2-Year Trajectory of Mental and Physical Health in Prostate Cancer Patients

Alessandro Cicchetti  1 , Marianna Noale  2 , Paola Dordoni  1 , Barbara Noris Chiorda  1 , Letizia De Luca  1 , Lara Bellardita  1 , Rodolfo Montironi  3 , Filippo Bertoni  4 , Pierfrancesco Bassi  5 , Riccardo Schiavina  6 , Mauro Gacci  7 , Sergio Serni  7 , Francesco Sessa  7 , Marco Maruzzo  8 , Stefania Maggi  2 , Riccardo Valdagni  1   9   10 ; Pros-IT CNR Study Group
Affiliations

Patient-Factors Influencing the 2-Year Trajectory of Mental and Physical Health in Prostate Cancer Patients

Alessandro Cicchetti et al. Curr Oncol. .

Abstract

This study aimed to examine the physical and mental Quality of Life (QoL) trajectories in prostate cancer (PCa) patients participating in the Pros-IT CNR study. QoL was assessed using the Physical (PCS) and Mental Component Score (MCS) of Short-Form Health Survey upon diagnosis and two years later. Growth mixture models were applied on 1158 patients and 3 trajectories over time were identified for MCS: 75% of patients had constantly high scores, 13% had permanently low scores and 12% starting with low scores had a recovery; the predictors that differentiated the trajectories were age, comorbidities, a family history of PCa, and the bowel, urinary and sexual functional scores at diagnosis. In the physical domain, 2 trajectories were defined: 85% of patients had constantly high scores, while 15% started with low scores and had a further slight decrease. Two years after diagnosis, the psychological and physical status was moderately compromised in more than 10% of PCa patients. For mental health, the trajectory analysis suggested that following the compromised patients at diagnosis until treatment could allow identification of those more vulnerable, for which a level 2 intervention with support from a non-oncology team supervised by a clinical psychologist could be of help.

Keywords: SF-12; growth mixture model; health related quality of life; prostate cancer.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow Diagram of the Pros-IT patients.
Figure 2
Figure 2
The mean MCS scores across the timeline of the 4 evaluations for the Pros-IT participants.
Figure 3
Figure 3
The PCS SF-12 scores across the timeline of the 4 evaluations for the Pros-IT participants.
Figure 4
Figure 4
(a) Distribution of MCS scores of the Pros-IT and ISTAT populations according to age groups; (b) Distribution of MCS scores in trajectories for Pros-IT participants and of the ISTAT cancer patients; (c) Distribution of PCS scores of the Pros-IT and ISTAT populations according to age groups; (d) Distribution of PCS scores in trajectories for Pros-IT participants and of the ISTAT cancer patients.
See this image and copyright information in PMC

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