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Review
. 2022 Nov 10;15(11):1380.
doi: 10.3390/ph15111380.

Modulation of Cytoskeleton, Protein Trafficking, and Signaling Pathways by Metabolites from Cucurbitaceae, Ericaceae, and Rosaceae Plant Families

Ankit Patel  1 , Aliyah Rasheed  1 , Isiah Reilly  1 , Zil Pareek  1 , Mattia Hansen  1 , Zayn Haque  1 , Daniela Simon-Fajardo  1 , Chloe Davies  1 , Akash Tummala  1 , Karlyn Reinhardt  1 , Alexandria Bustabad  1 , Maxwell Shaw  1 , Jasmine Robins  1 , Karolaent Vera Gomez  1 , Thitisuda Suphakorn  1 , Mariana Camacho Gemelgo  1 , Ashley Law  1 , Kristina Lin  1 , Elizabeth Hospedales  1 , Harrison Haley  1 , Jean Pierre Perez Martinez  1 , Saifullah Khan  1 , Jessica DeCanio  1 , Malcolm Padgett  1 , Artem Abramov  1 , Meera Nanjundan  1
Affiliations
Review

Modulation of Cytoskeleton, Protein Trafficking, and Signaling Pathways by Metabolites from Cucurbitaceae, Ericaceae, and Rosaceae Plant Families

Ankit Patel et al. Pharmaceuticals (Basel). .

Abstract

One promising frontier within the field of Medical Botany is the study of the bioactivity of plant metabolites on human health. Although plant metabolites are metabolic byproducts that commonly regulate ecological interactions and biochemical processes in plant species, such metabolites also elicit profound effects on the cellular processes of human and other mammalian cells. In this regard, due to their potential as therapeutic agents for a variety of human diseases and induction of toxic cellular responses, further research advances are direly needed to fully understand the molecular mechanisms induced by these agents. Herein, we focus our investigation on metabolites from the Cucurbitaceae, Ericaceae, and Rosaceae plant families, for which several plant species are found within the state of Florida in Hillsborough County. Specifically, we compare the molecular mechanisms by which metabolites and/or plant extracts from these plant families modulate the cytoskeleton, protein trafficking, and cell signaling to mediate functional outcomes, as well as a discussion of current gaps in knowledge. Our efforts to lay the molecular groundwork in this broad manner hold promise in supporting future research efforts in pharmacology and drug discovery.

Keywords: Cucurbitaceae; Ericaceae; Rosaceae; cytoskeleton; protein trafficking; signaling.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
The number of plant species of each plant family identified in Hillsborough County, Florida, United States. The triangles represent plant families; the blue arrows point to plant families with the highest number of species; the orange arrows point to plant families selected in this article.
Figure 2
Figure 2
A Venn-diagram representation of the diseases in which metabolites from each plant family have been reported, with respect to the PubMed, searches performed.
Figure 3
Figure 3
A schematic summary of the effects of metabolites from Cucurbitaceae on cytoskeletal alterations.
Figure 4
Figure 4
A schematic summary of the effects of metabolites from Ericaceae on cytoskeletal alterations.
Figure 5
Figure 5
A schematic summary of the effects of metabolites from Rosaceae on cytoskeletal alterations.
Figure 6
Figure 6
A schematic summary of the effects of metabolites from Cucurbitaceae on protein trafficking dynamics.
Figure 7
Figure 7
A schematic summary of the effects of metabolites from Ericaceae on protein trafficking dynamics.
Figure 8
Figure 8
A schematic summary of the effects of metabolites from Rosaceae on protein trafficking dynamics.
Figure 9
Figure 9
A schematic summary of the effects of metabolites from the Cucurbitaceae on the MAPK, PI3K/AKT, and JAK/STAT signal transduction pathways.
Figure 10
Figure 10
A schematic summary of the effects of metabolites from the Ericaceae on the MAPK, PI3K/AKT, and JAK/STAT signal transduction pathways.
Figure 11
Figure 11
A schematic summary of the effects of metabolites from the Rosaceae on the MAPK, PI3K/AKT, and JAK/STAT signal transduction pathways.
See this image and copyright information in PMC

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References

    1. Fabricant D.S., Farnsworth N.R. The value of plants used in traditional medicine for drug discovery. Environ. Health Perspect. 2001;109((Suppl. S1)):69–75. - PMC - PubMed
    1. Dhyani P., Quispe C., Sharma E., Bahukhandi A., Sati P., Attri D.C., Szopa A., Sharifi-Rad J., Docea A.O., Mardare I., et al. Anticancer potential of alkaloids: A key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine. Cancer Cell Int. 2022;22:206. doi: 10.1186/s12935-022-02624-9. - DOI - PMC - PubMed
    1. Zhang J., Hansen L.G., Gudich O., Viehrig K., Lassen L.M.M., Schrubbers L., Adhikari K.B., Rubaszka P., Carrasquer-Alvarez E., Chen L., et al. A microbial supply chain for production of the anti-cancer drug vinblastine. Nature. 2022;609:341–347. doi: 10.1038/s41586-022-05157-3. - DOI - PMC - PubMed
    1. Da Silva T.C., da Silva J.M., Ramos M.A. What Factors Guide the Selection of Medicinal Plants in a Local Pharmacopoeia? A Case Study in a Rural Community from a Historically Transformed Atlantic Forest Landscape. Evid. Based Complement. Alternat. Med. 2018;2018:2519212. doi: 10.1155/2018/2519212. - DOI - PMC - PubMed
    1. Kew RBG State of the World’s Plants 2017. Royal Botanic Gardens, Kew. 2017. [(accessed on 31 August 2022)]. Available online: https://stateoftheworldsplants.org/

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