Lack of relationship between 25-hydoxyvitamin D concentration and a titer of antibodies to hepatitis B surface antigen in children under 12 years of age
- PMID: 36355809
- PMCID: PMC9648759
- DOI: 10.1371/journal.pone.0277473
Lack of relationship between 25-hydoxyvitamin D concentration and a titer of antibodies to hepatitis B surface antigen in children under 12 years of age
Abstract
The effect of vitamin D levels on the response to the hepatitis B vaccine in childhood and the induced levels of antibodies against the hepatitis B surface antigen (anti-HBs) is not yet well understood. The study aimed to investigate the relationship between age, serum 25-hydroxyvitamin D (25(OH)D) concentration and anti-HBs titer among children under 12 years old. Serum 25(OH)D concentration and anti-HBs titer were determined in 352 healthy Caucasian children with the average age of 4.2 (2.5; 6.3) years. All children were vaccinated with 3 doses of hepatitis B vaccine (Engerix-B, GlaxoSmithKline Pharmaceuticals Limited) in infancy according to the Centers for Disease Control and Prevention recommendations. Only 14.5% of children had an optimal concentration of 25(OH)D ≥ 30 ng/mL and 71.9% children had a seroprotective anti-HBs titer ≥ 10 mIU/mL. Significant negative correlations were found between 25(OH)D, anti-HBs titer and age (r = -0.420, p = 0.000; r = -0.425, p = 0.000, respectively), and a weak positive correlation between 25(OH)D concentration and anti-HBs titer (r = 0.243, p = 0.000). Analysis of six clusters of children demonstrated that age is the main factor affecting anti-HBs titer. One third of children under 12 years of age had nonprotective anti-HBs titer < 10 mIU/mL and around 40% had vitamin D deficiency. We conclude that vitamin D status has no impact on anti-HBs titer in children vaccinated against hepatitis B virus in infancy. Age, so time since the receipt of the last dose of hepatitis B vaccine, is the main factor influencing a decline in anti-HBs titer.
Copyright: © 2022 Dabrowska-Leonik et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Conflict of interest statement
The authors have declared that no competing interests exist.
Figures
Similar articles
-
Age-dependent decrease of anti-HBs titers and effect of booster doses using 2 different vaccines in Palestinian children vaccinated in early childhood.Hum Vaccin Immunother. 2015;11(7):1717-24. doi: 10.1080/21645515.2015.1041687. Hum Vaccin Immunother. 2015. PMID: 25996579 Free PMC article.
-
Immunogenicity of compulsory and booster doses of hepatitis B vaccine among children in Cairo, Egypt.J Egypt Public Health Assoc. 2017 Jun 1;92(2):77-85. doi: 10.21608/epx.2018.8945. J Egypt Public Health Assoc. 2017. PMID: 30184404
-
The Serum Anti-HBs Level Among Children Who Received Routine Hepatitis B Vaccination During Infancy in Mianyang City, China: A Cross-Sectional Study.Viral Immunol. 2016 Jan-Feb;29(1):40-8. doi: 10.1089/vim.2015.0073. Epub 2015 Nov 13. Viral Immunol. 2016. PMID: 26565951
-
[Anti-HBs persistence following revaccination with three doses of hepatitis B vaccine among low-responsive adults after primary vaccination: a 4-year follow-up study].Zhonghua Yu Fang Yi Xue Za Zhi. 2016 Jun;50(6):491-6. doi: 10.3760/cma.j.issn.0253-9624.2016.06.004. Zhonghua Yu Fang Yi Xue Za Zhi. 2016. PMID: 27256727 Chinese.
-
The association of the vitamin D status with the persistence of anti-HBs antibody at 20years after primary vaccination with recombinant hepatitis B vaccine in infancy.Clin Res Hepatol Gastroenterol. 2017 Feb;41(1):66-74. doi: 10.1016/j.clinre.2016.06.005. Epub 2016 Jul 22. Clin Res Hepatol Gastroenterol. 2017. PMID: 27459879
Cited by
-
Correlation Between Vitamin D Status and HBsAg Antibody Levels in Indonesian Adolescents Immunised Against Hepatitis B.Int J Gen Med. 2023 Nov 8;16:5183-5192. doi: 10.2147/IJGM.S434290. eCollection 2023. Int J Gen Med. 2023. PMID: 38021059 Free PMC article.
-
Association between Vitamin D Deficiency and Serologic Response to Hepatitis B Virus Vaccination among Heavy Industry Workers.Vaccines (Basel). 2024 Jun 28;12(7):723. doi: 10.3390/vaccines12070723. Vaccines (Basel). 2024. PMID: 39066360 Free PMC article.
References
-
- Krugman S. The newly licensed hepatitis B vaccine. Characteristics and indications for use. JAMA. 1982. Apr;247(14):2012–2015. - PubMed
-
- Goudeau A, Dubois F, Barin F, Dubois MC, Coursaget P. Hepatitis B vaccine: clinical trials in high-risk settings in France. (September 1975–September 1982). Dev Biol Stand. 1983;54:267–284. - PubMed
-
- Polish mandatory immunisation schedule. http://dziennikmz.mz.gov.pl/DUM_MZ/2013/43/akt.pdf.
-
- Centers for Disease Control and Prevention. ttps://www.cdc.gov/vaccines/vpd/hepb/index.html.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical