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. 2022 Nov 4;7(11):352.
doi: 10.3390/tropicalmed7110352.

Asymptomatic Cryptosporidiosis in Children Living with HIV

Ajib Diptyanusa  1   2 , Ika Puspa Sari  3 , Agnes Kurniawan  3
Affiliations

Asymptomatic Cryptosporidiosis in Children Living with HIV

Ajib Diptyanusa et al. Trop Med Infect Dis. .

Abstract

Children living with human immunodeficiency virus (HIV) have an increased risk of opportunistic Cryptosporidium infection. Cryptosporidium usually causes chronic diarrhea that may lead to impaired growth and cognitive function in children. This study aimed to estimate the prevalence of cryptosporidiosis in children, describe its clinical characteristics, and the risk factors. A cross-sectional study involving children aged 6 months to 18 years old with confirmed HIV infection was carried out in Sardjito General Hospital, Yogyakarta. Diagnosis of cryptosporidiosis was made by PCR of 18S rRNA after being screened by microscopic examination. The clinical characteristics and risk factors were obtained from medical records and structured questionnaires. A total of 52 participants were included in the final analysis. The prevalence of cryptosporidiosis was 42.3%. Approximately 68% of the HIV children with cryptosporidiosis were asymptomatic, while those who reported symptoms showed weight loss and diarrhea. Independent risk factors of cryptosporidiosis were diarrhea (AOR 6.5; 95% CI 1.16-36.67), well water as drinking water source (AOR 6.7; 95% CI 1.83-24.93), and drink untreated water (AOR 5.8; 95% CI 1.04-32.64). A high prevalence of asymptomatic cryptosporidiosis was observed among children with HIV infection and PCR screening of Cryptosporidium in high-risk children is advisable.

Keywords: HIV; children; drinking water; opportunistic infection.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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References

    1. Ahmadpour E., Safarpour H., Xiao L., Zarean M., Hatam-Nahavandi K., Barac A., Picot S., Rahimi M.T., Rubino S., Mahami-Oskouei M., et al. Cryptosporidiosis in HIV-positive patients and related risk factors: A systematic review and meta-analysis. Parasite. 2020;27:27. doi: 10.1051/parasite/2020025. - DOI - PMC - PubMed
    1. Beeching N.J., Jones R., Gazzard B. Gastrointestinal opportunistic infections. HIV Med. 2011;12:43–54. doi: 10.1111/j.1468-1293.2011.00944_5.x. - DOI
    1. Pignata C., Bonetta S., Bonetta S., Cacciò S.M., Sannella A.R., Gilli G., Carraro E. Cryptosporidium Oocyst Contamination in Drinking Water: A Case Study in Italy. Int. J. Environ. Res. Public Health. 2019;16:2055. doi: 10.3390/ijerph16112055. - DOI - PMC - PubMed
    1. Utami W.S., Murhandarwati E.H., Artama W.T., Kusnanto H. Cryptosporidium Infection Increases the Risk for Chronic Diarrhea Among People Living With HIV in Southeast Asia: A Systematic Review and Meta-Analysis. Asia Pac. J. Public Health. 2020;32:8–18. doi: 10.1177/1010539519895422. - DOI - PMC - PubMed
    1. Fletcher S.M., Stark D., Harkness J., Ellis J. Enteric protozoa in the developed world: A public health perspective. Clin. Microbiol. Rev. 2012;25:420. doi: 10.1128/CMR.05038-11. - DOI - PMC - PubMed

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