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Editorial
. 2022 Nov 11;131(11):890-892.
doi: 10.1161/CIRCRESAHA.122.322035. Epub 2022 Nov 10.

PCSK9 Pleiotropism: In the Same Vein as Statins

Arick C Park  1 , Xiangyu Zhang  1 , Yu-Sheng Yeh  1 , Babak Razani  2   3
Affiliations
Editorial

PCSK9 Pleiotropism: In the Same Vein as Statins

Arick C Park et al. Circ Res. .
No abstract available

Keywords: Editorials; coronary artery disease; proprotein convertases; thrombosis; vascular grafting.

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Conflict of interest statement

Disclosures

The authors do not have any conflicts of interests.

Figures

Figure.
Figure.. PCSK9 Pleiotropism
PCSK9 contributes to intimal wall thickening in LDLR-deficient mice (left, top) and was shown to directly binds to SDC4 resulting in the upregulation of pro-inflammatory transcripts likely via NF-kb. This upregulation was only partially blocked by SDC4 knockdown, suggesting additional pathways yet to be uncovered (left, bottom). Potential parallel pathways in atherosclerosis (right). Atherosclerotic lesions express high levels of PSCK9, which can directly interact with macrophages to stimulate pro-inflammatory markers via NF-kb (Tang et al., 2017). SDC4 is atheroprotective. Loss of function results in endothelial misalignment with regard to blood flow and increased atherosclerosis (Baeyens et al., 2014)
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