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. 2022 Dec;37(6):783-785.
doi: 10.1016/j.virs.2022.11.002. Epub 2022 Nov 7.

Protection from infection or disease? Re-evaluating the broad immunogenicity of inactivated SARS-CoV-2 vaccines

Anthony T Tan  1 , Joey Ming Er Lim  1 , Antonio Bertoletti  2
Affiliations

Protection from infection or disease? Re-evaluating the broad immunogenicity of inactivated SARS-CoV-2 vaccines

Anthony T Tan et al. Virol Sin. 2022 Dec.

Abstract

  1. •

    Viral lineages that escape antibodies have changed the landscape of the pandemic.

  2. •

    SARS-CoV-2 specific T cells effectively protect against disease development.

  3. •

    Vaccine efficacy should be evaluated by its ability to protect from severe disease.

  4. •

    Inactivated SARS-CoV-2 vaccine induces a multi-protein specific T cell response.

  5. •

    The superior breadth of the vaccine T cell response could be a protective asset.

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Figures

Fig. 1
Fig. 1
Characteristics of spike mRNA and inactivated SARS-CoV-2 vaccine-induced T cell response. NP, nucleoprotein; Mem, membrane.
See this image and copyright information in PMC

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