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Review
. 2022;193(1):167-176.
doi: 10.1016/bs.pmbts.2022.06.007. Epub 2022 Jul 20.

The interaction, mechanism and function of GPR158-RGS7 cross-talk

Shradha V Darira  1 , Laurie P Sutton  2
Affiliations
Review

The interaction, mechanism and function of GPR158-RGS7 cross-talk

Shradha V Darira et al. Prog Mol Biol Transl Sci. 2022.

Abstract

GPR158 is an orphan G protein-coupled receptor (GPCR) that is broadly expressed in the brain and displays unique structural characteristics and signaling mechanisms. GPR158 is a binding partner for the regulator of G protein signaling 7 (RGS7) and augments its expression, subcellular localization, and catalytic activity. Recent cryo-electron microscopy (cryo-EM) studies have revealed the structure of GPR158 alone and in complex with RGS7. The GPR158-RGS7 complex is shown to be regulated by chronic stress exposure and is a modulator of stress-induced depression. This review highlights the signaling mechanism and function of GPR158-RGS7 and provides a context for the unique formation of GPCR-RGS complexes.

Keywords: Crystal structure; Depression; G protein signaling; GPCR; GPR158; Mood regulation; RGS7; Signaling complex; Stress; cAMP.

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