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Comment
. 2022 Dec;43(12):953-955.
doi: 10.1016/j.it.2022.10.009. Epub 2022 Nov 7.

Prenatal inflammation shapes microglial immune response into adulthood

Marianela E Traetta  1 , Marie-Ève Tremblay  2
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Prenatal inflammation shapes microglial immune response into adulthood

Marianela E Traetta et al. Trends Immunol. 2022 Dec.

Abstract

Hayes and collaborators recently unraveled that maternal immune activation in mice led to a long-lasting decrease in microglial immune reactivity. Thus, microglia exhibited a reduced immune response to a second proinflammatory stressor in adulthood. This altered microglial response impacted both astrocytic reactivity and neuronal circuitry.

Keywords: immune response; maternal immune activation; microglia; neurodegeneration; neurodevelopment.

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Conflict of interest statement

Declaration of interests No interests are declared.

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