Donor heart selection: Evidence-based guidelines for providers

Hannah Copeland¹, Ivan Knezevic², David A Baran³, Vivek Rao⁴, Michael Pham⁵, Finn Gustafsson⁶, Sean Pinney⁷, Brian Lima⁸, Marco Masetti⁹, Agnieszka Ciarka¹⁰, Navin Rajagopalan¹¹, Adriana Torres¹², Eileen Hsich¹³, Jignesh K Patel¹⁴, Livia Adams Goldraich¹⁵, Monica Colvin¹⁶, Javier Segovia¹⁷, Heather Ross¹⁸, Mahazarin Ginwalla¹⁹, Babak Sharif-Kashani²⁰, MaryJane A Farr²¹, Luciano Potena⁹, Jon Kobashigawa¹⁴, Maria G Crespo-Leiro²², Natasha Altman²³, Florian Wagner²⁴, Jennifer Cook²⁵, Valentina Stosor²⁶, Paolo A Grossi²⁷, Kiran Khush²⁸, Tahir Yagdi²⁹, Susan Restaino³⁰, Steven Tsui³¹, Daniel Absi³², George Sokos³³, Andreas Zuckermann³⁴, Brian Wayda²⁸, Joost Felius³⁵, Shelley A Hall³⁶

Affiliations

¹ Department of Cardiovascular and Thoracic Surgery Lutheran Hospital, Fort Wayne, Indiana; Indiana University School of Medicine-Fort Wayne, Fort Wayne, Indiana. Electronic address: hannahcopeland411@gmail.com.
² Transplantation Centre, University Medical Centre Ljubljana, Ljubljana, Slovenia.
³ Department of Medicine, Division of Cardiology, Sentara Heart Hospital, Norfolk, Virginia.
⁴ Peter Munk Cardiac Centre Toronto General Hospital, Toronto, Ontario, Canada; University of Toronto, Toronto, Ontario, Canada.
⁵ Sutter Health California Pacific Medical Center, San Francisco, California.
⁶ Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
⁷ University of Chicago Medicine, Chicago, Illinois.
⁸ Medical City Heart Hospital, Dallas, Texas.
⁹ Heart Failure and Heart Transplant Unit IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy.
¹⁰ Department of Cardiovascular Diseases, Katholieke Universiteit Leuven, Leuven, Belgium; Institute of Civilisation Diseases and Regenerative Medicine, University of Information Technology and Management, Rzeszow, Poland.
¹¹ University of Kentucky, Lexington, Kentucky.
¹² Los Cobos Medical Center, Universidad El Bosque, Bogota, Colombia.
¹³ Cleveland Clinic, Cleveland, Ohio.
¹⁴ Cedars Sinai Smidt Heart Institute, Los Angeles, California.
¹⁵ Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil.
¹⁶ University of Michigan, Ann Arbor, Michigan.
¹⁷ Cardiology Department, Hospital Universitario Puerta de Hierro, Universidad Autónoma de Madrid, Madrid, Spain.
¹⁸ University of Toronto, Toronto, Ontario, Canada; Sutter Health California Pacific Medical Center, San Francisco, California.
¹⁹ Cardiovascular Division, Palo Alto Medical Foundation/Sutter Health, Burlingame, California.
²⁰ Department of Cardiology, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
²¹ Department of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas.
²² University Hospital Complex of La Coruña (CIBERCV), La Coruña, Spain.
²³ University of Colorado, Aurora, Colorado.
²⁴ University of Hamburg, Hamburg, Germany.
²⁵ University of Cincinnati, Cincinnati, Ohio.
²⁶ Northwestern University Feinberg School of Medicine, Chicago, Illinois.
²⁷ University of Insubria, Varese, Italy.
²⁸ Division of Cardiovascular Medicine, Stanford University, Stanford, California.
²⁹ Department of Cardiovascular Surgery, Ege University School of Medicine, Izmir, Turkey.
³⁰ Division of Cardiology Columbia University, New York, New York; New York Presbyterian Hospital, New York, New York.
³¹ Department of Cardiothoracic Surgery Royal Papworth Hospital NHS Foundation Trust, Cambridge, United Kingdom.
³² Department of Cardiothoracic and Transplant Surgery, University Hospital Favaloro Foundation, Buenos Aires, Argentina.
³³ Heart and Vascular Institute, West Virginia University, Morgantown, West Virginia.
³⁴ Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.
³⁵ Baylor Scott & White Research Institute, Dallas, Texas; Texas A&M University Health Science Center, Dallas, Texas.
³⁶ Texas A&M University Health Science Center, Dallas, Texas; Division of Transplant Cardiology, Mechanical Circulatory Support and Advanced Heart Failure, Baylor University Medical Center, Dallas, Texas.

PMID: 36357275
PMCID: PMC10284152
DOI: 10.1016/j.healun.2022.08.030

Practice Guideline

Donor heart selection: Evidence-based guidelines for providers

Hannah Copeland et al. J Heart Lung Transplant. 2023 Jan.

. 2023 Jan;42(1):7-29.

doi: 10.1016/j.healun.2022.08.030. Epub 2022 Sep 20.

Authors

Affiliations

¹ Department of Cardiovascular and Thoracic Surgery Lutheran Hospital, Fort Wayne, Indiana; Indiana University School of Medicine-Fort Wayne, Fort Wayne, Indiana. Electronic address: hannahcopeland411@gmail.com.
² Transplantation Centre, University Medical Centre Ljubljana, Ljubljana, Slovenia.
³ Department of Medicine, Division of Cardiology, Sentara Heart Hospital, Norfolk, Virginia.
⁴ Peter Munk Cardiac Centre Toronto General Hospital, Toronto, Ontario, Canada; University of Toronto, Toronto, Ontario, Canada.
⁵ Sutter Health California Pacific Medical Center, San Francisco, California.
⁶ Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
⁷ University of Chicago Medicine, Chicago, Illinois.
⁸ Medical City Heart Hospital, Dallas, Texas.
⁹ Heart Failure and Heart Transplant Unit IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy.
¹⁰ Department of Cardiovascular Diseases, Katholieke Universiteit Leuven, Leuven, Belgium; Institute of Civilisation Diseases and Regenerative Medicine, University of Information Technology and Management, Rzeszow, Poland.
¹¹ University of Kentucky, Lexington, Kentucky.
¹² Los Cobos Medical Center, Universidad El Bosque, Bogota, Colombia.
¹³ Cleveland Clinic, Cleveland, Ohio.
¹⁴ Cedars Sinai Smidt Heart Institute, Los Angeles, California.
¹⁵ Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil.
¹⁶ University of Michigan, Ann Arbor, Michigan.
¹⁷ Cardiology Department, Hospital Universitario Puerta de Hierro, Universidad Autónoma de Madrid, Madrid, Spain.
¹⁸ University of Toronto, Toronto, Ontario, Canada; Sutter Health California Pacific Medical Center, San Francisco, California.
¹⁹ Cardiovascular Division, Palo Alto Medical Foundation/Sutter Health, Burlingame, California.
²⁰ Department of Cardiology, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
²¹ Department of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas.
²² University Hospital Complex of La Coruña (CIBERCV), La Coruña, Spain.
²³ University of Colorado, Aurora, Colorado.
²⁴ University of Hamburg, Hamburg, Germany.
²⁵ University of Cincinnati, Cincinnati, Ohio.
²⁶ Northwestern University Feinberg School of Medicine, Chicago, Illinois.
²⁷ University of Insubria, Varese, Italy.
²⁸ Division of Cardiovascular Medicine, Stanford University, Stanford, California.
²⁹ Department of Cardiovascular Surgery, Ege University School of Medicine, Izmir, Turkey.
³⁰ Division of Cardiology Columbia University, New York, New York; New York Presbyterian Hospital, New York, New York.
³¹ Department of Cardiothoracic Surgery Royal Papworth Hospital NHS Foundation Trust, Cambridge, United Kingdom.
³² Department of Cardiothoracic and Transplant Surgery, University Hospital Favaloro Foundation, Buenos Aires, Argentina.
³³ Heart and Vascular Institute, West Virginia University, Morgantown, West Virginia.
³⁴ Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.
³⁵ Baylor Scott & White Research Institute, Dallas, Texas; Texas A&M University Health Science Center, Dallas, Texas.
³⁶ Texas A&M University Health Science Center, Dallas, Texas; Division of Transplant Cardiology, Mechanical Circulatory Support and Advanced Heart Failure, Baylor University Medical Center, Dallas, Texas.

PMID: 36357275
PMCID: PMC10284152
DOI: 10.1016/j.healun.2022.08.030

Abstract

The proposed donor heart selection guidelines provide evidence-based and expert-consensus recommendations for the selection of donor hearts following brain death. These recommendations were compiled by an international panel of experts based on an extensive literature review.

Keywords: brain death; donor heart; donor risk factors; heart transplant; selection.

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References

1. Copeland JG. Only optimal donors should be accepted for heart transplantation: protagonist. J Heart Lung Transplant 1995;14(6 Pt 1):1038–42. - PubMed
1. International Society for Heart Lung Transplantation. Protocol and policies for developing standards statements, guidelines, and consensus documents and for conducting consensus conferences. 2017; https://ishlt.org/ishlt/media/documents/STANDARDS_AND_GUIDELINES_DEVELOP...
1. Dhar R, Cotton C, Coleman J, et al. Comparison of high- and low-dose corticosteroid regimens for organ donor management. J Crit Care 2013;28. 111.e111–117. - PubMed
1. Dupuis S, Amiel JA, Desgroseilliers M, et al. Corticosteroids in the management of brain-dead potential organ donors: a systematic review. Br J Anaesth 2014;113:346–59. - PubMed
1. Pinsard M, Ragot S, Mertes PM, et al. Interest of low-dose hydrocortisone therapy during brain-dead organ donor resuscitation: the CORTICOME study. Crit Care 2014;18:R158. - PMC - PubMed

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Donor heart selection: Evidence-based guidelines for providers

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Donor heart selection: Evidence-based guidelines for providers

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Abstract

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