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. 2022 Nov 10;12(1):474.
doi: 10.1038/s41398-022-02235-y.

Superior temporal gyrus and cerebellar loops predict nonsuicidal self-injury in major depressive disorder patients by multimodal neuroimaging

Lijun Kang  1 , Wei Wang  1 , Nan Zhang  1 , Zhaowen Nie  1 , Qian Gong  1 , Lihua Yao  1 , Ning Tu  2 , Hongyan Feng  2 , Xiaofen Zong  1 , Hanping Bai  1 , Gaohua Wang  1 , Lihong Bu  3 , Fei Wang  4   5 , Zhongchun Liu  6   7
Affiliations

Superior temporal gyrus and cerebellar loops predict nonsuicidal self-injury in major depressive disorder patients by multimodal neuroimaging

Lijun Kang et al. Transl Psychiatry. .

Abstract

In major depressive disorder (MDD) patients, nonsuicidal self-injury (NSSI) is a common comorbidity, and it is important to clarify the underlying neurobiology. Here, we investigated the association of NSSI with brain function and structure in MDD patients. A total of 260 MDD patients and 132 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging and three-dimensional T1-weighted structural scans. NSSI behaviour was assessed through interviews. Voxel-based morphometry analysis (VBM), regional homogeneity analysis (ReHo), functional connectome topology properties and network-based statistics were used to detect the differences in neuroimaging characteristics. Finally, the random forest method was used to evaluate whether these factors could predict NSSI in MDD. Compared with HCs, MDD patients with a history of NSSI showed significant right putamen grey matter volume (GMV), right superior orbital frontal cortex ReHo, left pallidum degree centrality, and putamen-centre function network differences. Compared to MDD subjects without NSSI, those with past NSSI showed significant right superior temporal gyrus (STG) GMV, right lingual gyrus ReHo, sigma and global efficiency, and cerebellum-centre function network differences. The right STG GMV and cerebellum-centre function network were more important than other factors in predicting NSSI behaviour in MDD. MDD patients with a history of NSSI have dysregulated spontaneous brain activity and structure in regions related to emotions, pain regulation, and the somatosensory system. Importantly, right STG GMV and cerebellar loops may play important roles in NSSI in MDD patients.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Comparison GMV and ReHo of between MDD with NSSI and HCs, and MDD with and without NSSI.
a, b Show the difference in Reho. c, d Show the difference in GMV. MDD major depressive disorder, NSSI nonsuicidal self-injury, HCs healthy controls, GMV grey matter volume, ReHo regional homogeneity analysis.
Fig. 2
Fig. 2. Comparison of global connectome topology differences between different groups.
a–d Comparisons between MDD patients with NSSI and HCs and MDD patients with and without NSSI of Cp, Lp, Sigma and Eg. MDD major depressive disorder, NSSI nonsuicidal self-injury, HCs healthy controls, Cp clustering coefficient, Lp path length, Eg global efficiency.
Fig. 3
Fig. 3. Network-based statistics difference between MDD with NSSI and HCs and MDD with and without NSSI.
MDD major depressive disorder, NSSI nonsuicidal self-injury, HCs healthy controls.
See this image and copyright information in PMC

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