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. 2022 Nov 10;22(1):274.
doi: 10.1186/s12902-022-01180-7.

Relationship between a novel non-insulin-based metabolic score for insulin resistance (METS-IR) and coronary artery calcification

Zhenwei Wang #  1 , Xiaofang Hui #  2 , Xu Huang  1 , Jingjie Li  3 , Naifeng Liu  4
Affiliations

Relationship between a novel non-insulin-based metabolic score for insulin resistance (METS-IR) and coronary artery calcification

Zhenwei Wang et al. BMC Endocr Disord. .

Abstract

Background and aims: A novel non-insulin-based metabolic score for insulin resistance (METS-IR) index has been proposed as a simple and reliable alternative insulin resistance (IR) marker, but its the predictive value in asymptomatic adults with coronary artery calcification (CAC) remains unclear.

Methods and results: We enrolled 1576 participants without cardiovascular disease (CVD), who underwent multidetector computed tomography. Logistic regression, restricted cubic spline models and receiver operating characteristic (ROC) curves were used to examine the association between METS-IR, the ratio of triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) and triglyceride glucose index (TyG index) and CAC. In multivariate logistic regression analysis, the increase in METS-IR was independently associated with a higher prevalence of CAC (all P < 0.05 in Models 1-3). Furthermore, restricted cubic splines indicated that the significance of METS-IR in predicting CAC was higher than that of other IR indexes. In ROC curve analysis, without considering the P value, the area under the curve of CAC predicted by METS-IR was higher than that of other IR indexes (METS-IR, 0.607; TyG index, 0.603; TG/HDL-C, 0.577).

Conclusion: Compared with other IR indexes, METS-IR may have better discrimination ability in predicting the incidence of CAC in asymptomatic adults without CVD.

Keywords: Coronary artery calcification; Insulin resistance; Metabolic score for insulin resistance; Triglyceride glucose index.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Fig. 1
Fig. 1
Flow chart of the study participants. TG triglyceride, HDL-C high-density lipoprotein cholesterol, BMI Body mass index, METS-IR metabolic score for insulin resistance, CAC coronary artery calcification
Fig. 2
Fig. 2
Restricted cubic spline plots of the association between METS-IR (A), TyG index (B) and TG/HDL-C (C) with CAC. The associations were adjusted for age, sex, smoking, diabetes, hypertension, systolic blood pressure, diastolic blood pressure, total cholesterol, low-density lipoprotein cholesterol, creatinine, high sensitivity C-reactive protein, hemoglobin Alc. CAC coronary artery calcification, METS-IR metabolic score for insulin resistance, TyG index triglyceride-glucose index, TG triglyceride, HDL-C high-density lipoprotein cholesterol
Fig. 3
Fig. 3
C-statistics evaluating incremental effects of different models. METS-IR metabolic score for insulin resistance, TyG triglyceride-glucose index, TG triglyceride, HDL-C high-density lipoprotein cholesterol, AUC area under the curve
See this image and copyright information in PMC

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