Demographic, Reproductive, and Medical Risk Factors for Intrauterine Device Expulsion

Abstract

Objective: To explore to what extent intrauterine device (IUD) expulsion is associated with demographic and clinical risk factors.

Methods: The APEX-IUD (Association of Perforation and Expulsion of IntraUterine Devices) study was a U.S. cohort study using electronic health records from three integrated health care systems (Kaiser Permanente Northern California, Southern California, and Washington) and a health care information exchange (Regenstrief Institute). These analyses included individuals aged 50 years or younger with IUD insertions from 2001 to 2018. Intrauterine device expulsion cumulative incidence and incidence rates were estimated. Using Cox regression models, hazard ratios with 95% CIs were estimated before and after adjustment for risk factors of interest (age, race and ethnicity, parity, body mass index [BMI], heavy menstrual bleeding, and dysmenorrhea) and potential confounders.

Results: In total, 228,834 individuals with IUD insertion and no delivery in the previous 52 weeks were identified (184,733 [80.7%] with levonorgestrel-releasing intrauterine system). Diagnosis of heavy menstrual bleeding-particularly a diagnosis in both recent and past periods-was the strongest risk factor for IUD expulsion. Categories with the highest risk of IUD expulsion within each risk factor included individuals diagnosed with overweight, obesity, and morbid obesity; those in younger age groups, especially among those aged 24 years or younger; and in those with parity of four or more. Non-Hispanic White individuals had the lowest incidence and risk, and after adjustment, Asian or Pacific Islander individuals had the highest risk. Dysmenorrhea was not independently associated with expulsion risk when adjusting for heavy menstrual bleeding.

Conclusion: Most risk factors for expulsion identified in this study appear consistent with known physiologic factors that affect uterine anatomy and physiology (age, BMI, heavy menstrual bleeding, parity). The increased risk of IUD expulsion among individuals of color warrants further investigation. Intrauterine devices are an effective long-term contraceptive; expulsion is uncommon, but patients should be counseled accordingly.

Funding source: Bayer AG.

Clinical trial registration: EU PAS register, EUPAS33461.

Fig. 1.. Analysis population. *Individuals who were 52 weeks or less postpartum were excluded to reduce the effects of confounding by breastfeeding and early postpartum timing of intrauterine device (IUD) insertion and the effect of pregnancy on measurement of body mass index. APEX- IUD, Association of Perforation and EXpulsion of IntraUterine Devices; KPNC, Kaiser Permanente Northern California; KPSC, Kaiser Permanente Southern California; KPWA, Kaiser Permanente Washington; LNG-IUD, levonorgestrel-releasing intrauterine system.

Fig. 2.. Pooled crude and adjusted hazard ratios of intrauterine device (IUD) expulsion. Adjusted hazard ratios (HRs) were estimated from a Cox model including body mass index (BMI), menorrhagia diagnosis, age, parity, race and ethnicity, dysmenorrhea diagnosis, site, IUD type, calendar year of index date, leiomyomas, any concomitant gynecologic procedures, any indicator of difficult insertion, and annualized number of IUD insertions performed by a health care professional in the previous year. Percentage of insertions missing BMI category: 2.2%; percentage of insertions missing parity: 18.3%; percentage of insertions with unknown race and ethnicity: 2.3%. Hispanic other included individuals who indicated Hispanic ethnicity and either selected “other” for race or did not select a race at all. HMB, heavy menstrual bleeding.

Fig. 3.. Crude and adjusted hazard ratios of intrauterine device (IUD) expulsion by IUD type. For each IUD type, adjusted hazard ratios (HRs) were estimated from a Cox model including body mass index (BMI), menorrhagia diagnosis, age, parity, race and ethnicity, dysmenorrhea diagnosis, site, calendar year of index date, leiomyomas, any concomitant gynecologic procedures, any indicator of difficult insertion, and annualized number of IUD insertions performed by a health care professional in the previous year. Percentage of insertions missing BMI category, levonorgestrel-releasing intrauterine system (LNG-IUD): 2.2%; copper IUD: 1.3%; percentage of insertions missing parity, LNG-IUD: 18.0%; copper IUD: 16.5%; percentage of insertions with unknown race and ethnicity: LNG-IUD, 2.2%; copper IUD, 2.6%. Hispanic other included individuals who indicated Hispanic ethnicity and either selected “other” for race or did not select a race at all. HMB, heavy menstrual bleeding.

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