Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Oct 28;11(11):2136.
doi: 10.3390/antiox11112136.

Hydrogen Sulfide Biomedical Research in China-20 Years of Hindsight

Rui Wang  1 , Chaoshu Tang  2
Affiliations
Review

Hydrogen Sulfide Biomedical Research in China-20 Years of Hindsight

Rui Wang et al. Antioxidants (Basel). .

Abstract

Hydrogen sulfide (H2S) is an important gasotransmitter that is produced by mammalian cells and performs profound physiological and pathophysiological functions. Biomedical research on H2S metabolism and function in China began 20 years ago, which pioneered the examination of the correlation of abnormal H2S metabolism and cardiovascular diseases. Over the last two decades, research teams in China have made numerous breakthrough discoveries on the effects of H2S metabolism on hypertension, atherosclerosis, pulmonary hypertension, shock, angiogenesis, chronic obstructive pulmonary disease, pain, iron homeostasis, and testicle function, to name a few. These research developments, carried by numerous research teams all over China, build nationwide research network and advance both laboratory study and clinical applications. An integrated and collaborative research strategy would further promote and sustain H2S biomedical research in China and in the world.

Keywords: angiogenesis; atherosclerosis; chronic obstructive pulmonary disease (COPD); gasotransmitter; heart failure; hydrogen sulfide; hypertension; pain; reproduction; therapeutic.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Trends and intensities of biomedical research on H2S in China. (a) The numbers of publications on H2S biology and medicine by Chinese researchers. (b) The NSFC-sponsored research projects on biomedical research of H2S held in China.
Figure 2
Figure 2
Global and regional distributions of the research publications on H2S biology and medicine. (a) Top 10 countries with the most H2S biomedical research publications. (b) Top 20 Institutional affiliations of H2S biomedical research publications in China.
Figure 3
Figure 3
Chinese national research teams and funding agencies for H2S biomedical research. (a) Active H2S biomedical research teams in China. (b) Top 20 research funding agencies and authorities in China who sponsored H2S biomedical research publications from Chinese research teams.
Figure 4
Figure 4
Brainstorm discussion of the authors in 2001 in Beijing, China.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Zhang J., Lei D., Feng W. Analysis of chemical disasters caused by release of hydrogen sulfide-bearing natural gas. Procedia Eng. 2011;26:1878–1890.
    1. Wang R. Two’s company, three’s a crowd—Can H2S be the third endogenous gaseous transmitter? FASEB J. 2002;16:1792–1798. doi: 10.1096/fj.02-0211hyp. - DOI - PubMed
    1. Wang R. Physiological implications of hydrogen sulfide: A whiff exploration that blossomed. Physiol. Rev. 2012;92:791–896. doi: 10.1152/physrev.00017.2011. - DOI - PubMed
    1. Yang J., Minkler P., Grove D., Wang R., Willard B., Dweik R., Hine C. Non-enzymatic hydrogen sulfide production from cysteine in blood is catalyzed by iron and vitamin B6. Commun. Biol. 2019;2:194. doi: 10.1038/s42003-019-0431-5. - DOI - PMC - PubMed
    1. Searcy D.G., Lee S.H. Sulfur reduction by human erythrocytes. J. Exp. Zool. 1998;282:310–322. doi: 10.1002/(SICI)1097-010X(19981015)282:3<310::AID-JEZ4>3.0.CO;2-P. - DOI - PubMed

LinkOut - more resources