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Review
. 2022 Oct 26;14(21):5251.
doi: 10.3390/cancers14215251.

HDACi: The Columbus' Egg in Improving Cancer Treatment and Reducing Neurotoxicity?

Angelica Squarzoni  1   2 , Arianna Scuteri  1 , Guido Cavaletti  1
Affiliations
Review

HDACi: The Columbus' Egg in Improving Cancer Treatment and Reducing Neurotoxicity?

Angelica Squarzoni et al. Cancers (Basel). .

Abstract

Histone deacetylases (HDACs) are a group of enzymes that modify gene expression through the lysine acetylation of both histone and non-histone proteins, leading to a broad range of effects on various biological pathways. New insights on this topic broadened the knowledge on their biological activity and even more questions arose from those discoveries. The action of HDACs is versatile in biological pathways and, for this reason, inhibitors of HDACs (HDACis) have been proposed as a way to interfere with HDACs' involvement in tumorigenesis. In 2006, the first HDACi was approved by FDA for the treatment of cutaneous T-cell lymphoma; however, more selective HDACis were recently approved. In this review, we will consider new information on HDACs' expression and their regulation for the treatment of central and peripheral nervous system diseases.

Keywords: HATs; HDAC inhibitors; HDAC5; HDAC6; HDACs; central nervous system; nervous system; neurons; peripheral nervous system.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The balance between HATs and HDACs is crucial to the well-being of cells and organisms. The action of HDACs lowers gene transcription. On the contrary, when HDACs are repressed, the effect of HATs is stronger and leads to higher levels of gene transcription.
Figure 2
Figure 2
Localization of HDACs in the cell.
Figure 3
Figure 3
Graphic illustration of roles of HDACs in neurons.
See this image and copyright information in PMC

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