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Review
. 2022 Oct 28;14(21):5304.
doi: 10.3390/cancers14215304.

MicroRNAs' Crucial Role in Salivary Gland Cancers' Onset and Prognosis

Marco Bocchetti  1   2 , Piera Grisolia  1   2 , Federica Melisi  1   2 , Maria Grazia Ferraro  3   4 , Pietro De Luca  5   6 , Angelo Camaioni  6 , Michela Falco  1 , Marianna Abate  1 , Gabriella Misso  1 , Roberto Alfano  7 , Nunzio Accardo  8 , Flavia Oliva  8 , Alessia Maria Cossu  1   2 , Michele Caraglia  1   2 , Marianna Scrima  2 , Filippo Ricciardiello  8
Affiliations
Review

MicroRNAs' Crucial Role in Salivary Gland Cancers' Onset and Prognosis

Marco Bocchetti et al. Cancers (Basel). .

Abstract

Salivary gland cancer (SGC) is an uncommon and heterogeneous disease that accounts for around 8.5% of all head and neck cancers. MicroRNAs (miRNAs) consist of a class of highly conserved, short, single-stranded segments (18-25 nucleotides) of noncoding RNA that represent key gene-transcription regulators in physiological and pathological human conditions. However, their role in SGC development and progression is not completely clear. This review aims to compile and summarize the recent findings on the topic, focusing on the prognostic and diagnostic value of the major modulated and validated microRNAs in SGC. Their differential expression could possibly aid the clinician in delivering an early diagnosis, therapeutic strategy and precision medicine.

Keywords: biomarkers; diagnosis; microRNAs; prognosis; salivary gland cancer.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic representation of salivary gland cancer features and prevalence in the major glands.
Figure 2
Figure 2
MicroRNA: biogenesis and biological functions.
Figure 3
Figure 3
Liquid biopsy scheme.
See this image and copyright information in PMC

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