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Review
. 2022 Oct 26;12(21):2935.
doi: 10.3390/ani12212935.

Modulation of Host Antiviral Innate Immunity by African Swine Fever Virus: A Review

Wen-Rui He  1 , Jin Yuan  1 , Yu-He Ma  1 , Cheng-Yan Zhao  1 , Zhong-Yuan Yang  1 , Yuhang Zhang  1 , Shichong Han  1 , Bo Wan  1 , Gai-Ping Zhang  1
Affiliations
Review

Modulation of Host Antiviral Innate Immunity by African Swine Fever Virus: A Review

Wen-Rui He et al. Animals (Basel). .

Abstract

African swine fever (ASF), caused by African swine fever virus (ASFV), is a highly contagious and fatal disease found in swine. However, the viral proteins and mechanisms responsible for immune evasion are poorly understood, which has severely hindered the development of vaccines. This review mainly focuses on studies involving the innate antiviral immune response of the host and summarizes the latest studies on ASFV genes involved in interferon (IFN) signaling and inflammatory responses. We analyzed the effects of candidate viral proteins on ASFV infection, replication and pathogenicity and identified potential molecular targets for novel ASFV vaccines. These efforts will contribute to the construction of novel vaccines and wonder therapeutics for ASF.

Keywords: African swine fever virus; JAK-STAT pathway; cGAS-STING pathway; inflammatory response; innate immune response.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Molecular mechanisms and regulation of cGAS-STING and IFN signaling.
Figure 2
Figure 2
Molecular mechanisms and regulation of TNF-α/IL-1β-triggered signaling.
See this image and copyright information in PMC

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