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. 2022 Oct 29;10(11):2752.
doi: 10.3390/biomedicines10112752.

Potential Effects of Non-Surgical Periodontal Therapy on Periodontal Parameters, Inflammatory Markers, and Kidney Function Indicators in Chronic Kidney Disease Patients with Chronic Periodontitis

Ahmed Chaudhry  1   2 , Nur Karyatee Kassim  2   3   4 , Siti Lailatul Akmar Zainuddin  1   2 , Haslina Taib  1   2 , Hanim Afzan Ibrahim  2   3   4 , Basaruddin Ahmad  2   5 , Muhammad Hafiz Hanafi  2   6 , Azreen Syazril Adnan  7
Affiliations

Potential Effects of Non-Surgical Periodontal Therapy on Periodontal Parameters, Inflammatory Markers, and Kidney Function Indicators in Chronic Kidney Disease Patients with Chronic Periodontitis

Ahmed Chaudhry et al. Biomedicines. .

Abstract

Chronic kidney disease (CKD) and chronic periodontitis (CP) contribute to the increased level of inflammatory biomarkers in the blood. This study hypothesized that successful periodontal treatment would reduce the level of inflammatory biomarkers in CKD patients. This prospective study recruited two groups of CP patients: 33 pre-dialysis CKD patients and 33 non-CKD patients. All patients underwent non-surgical periodontal therapy (NSPT). Their blood samples and periodontal parameters were taken before and after six weeks of NSPT. The serum level of high-sensitivity C-reactive protein (hs-CRP), interleukin 6 (IL-6), and periodontal parameters were compared between groups. On the other hand, kidney function indicators such as serum urea and estimated glomerular filtration rate (eGFR) were only measured in CKD patients. Clinical periodontal parameters and inflammatory markers levels at baseline were significantly higher (p < 0.05) in the CKD group than in the non-CKD group and showed significant reduction (p < 0.05) after six weeks of NSPT. CKD patients demonstrated a greater periodontitis severity and higher inflammatory burden than non-CKD patients. Additionally, CKD patients with CP showed a good response to NSPT. Therefore, CKD patients’ periodontal health needs to be screened for early dental interventions and monitored accordingly.

Keywords: chronic kidney disease; inflammatory markers; periodontitis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Algorithm of patient recruitment. HUSM, Hospital Universiti Sains Malaysia; CRP, C-reactive protein; IL-6, interleukin 6, NSPT, non-surgical periodontal therapy; SRP, scaling, and root planning.
See this image and copyright information in PMC

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