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. 2022 Nov 1;10(11):2770.
doi: 10.3390/biomedicines10112770.

Are Antisense Long Non-Coding RNA Related to COVID-19?

Eman Ae Badr  1 , Ibrahim Eltantawy El Sayed  2 , Mohanad Kareem Razak Gabber  2 , Eman Abd Elrehem Ghobashy  3 , Abdullah G Al-Sehemi  4   5 , Hamed Algarni  4   6 , Yasser As Elghobashy  1
Affiliations

Are Antisense Long Non-Coding RNA Related to COVID-19?

Eman Ae Badr et al. Biomedicines. .

Abstract

Fighting external pathogens relies on the tight regulation of the gene expression of the immune system. Ferroptosis, which is a distinct form of programmed cell death driven by iron, is involved in the enhancement of follicular helper T cell function during infection. The regulation of RNA is a key step in final gene expression. The present study aimed to identify the expression level of antisense lncRNAs (A2M-AS1, DBH-AS1, FLVCR1-DT, and NCBP2AS2-1) and FLVCR1 in COVID-19 patients and its relation to the severity of the disease. COVID-19 patients as well as age and gender-matched healthy controls were enrolled in this study. The expression level of the antisense lncRNAs was measured by RT-PCR. Results revealed the decreased expression of A2M-AS1 and FLVCR1 in COVID-19 patients. Additionally, they showed the increased expression of DBH-AS1, FLVCR1-DT, and NCBP2AS2. Both FLVCR1-DT and NCBP2AS2 showed a positive correlation with interleukin-6 (IL-6). DBH-AS1 and FLVCR1-DT had a significant association with mortality, complications, and mechanical ventilation. A significant negative correlation was found between A2M-AS1 and NCBP2AS2-1 and between FLVCR1 and FLVCR1-DT. The study confirmed that the expression level of the antisense lncRNAs was deregulated in COVID-19 patients and correlated with the severity of COVID-19, and that it may have possible roles in the pathogenesis of this disease.

Keywords: A2M-AS1; COVID-19; DBH-AS1; FLVCR1; FLVCR1-DT; LncRNAs.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

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