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Review
. 2022 Nov 9;10(11):2864.
doi: 10.3390/biomedicines10112864.

Immunosenescence in Neurological Diseases-Is There Enough Evidence?

Paulus S Rommer  1 , Gabriel Bsteh  1 , Tobias Zrzavy  1 , Romana Hoeftberger  2 , Thomas Berger  1
Affiliations
Review

Immunosenescence in Neurological Diseases-Is There Enough Evidence?

Paulus S Rommer et al. Biomedicines. .

Abstract

The aging of the immune system has recently attracted a lot of attention. Immune senescence describes changes that the immune system undergoes over time. The importance of immune senescence in neurological diseases is increasingly discussed. For this review, we considered studies that investigated cellular changes in the aging immune system and in neurological disease. Twenty-six studies were included in our analysis (for the following diseases: multiple sclerosis, stroke, Parkinson's disease, and dementia). The studies differed considerably in terms of the patient groups included and the cell types studied. Evidence for immunosenescence in neurological diseases is currently very limited. Prospective studies in well-defined patient groups with appropriate control groups, as well as comprehensive methodology and reporting, are essential prerequisites to generate clear insights into immunosenescence in neurological diseases.

Keywords: Alzheimer’s disease; Parkinson’s disease; aging immune system; dementia; immunosenescence; multiple sclerosis; neurological disorders; stroke.

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Conflict of interest statement

The authors declare no conflict of interest with regard to the content of this article.

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