A Computerized Analysis with Machine Learning Techniques for the Diagnosis of Parkinson's Disease: Past Studies and Future Perspectives
- PMID: 36359550
- PMCID: PMC9689408
- DOI: 10.3390/diagnostics12112708
A Computerized Analysis with Machine Learning Techniques for the Diagnosis of Parkinson's Disease: Past Studies and Future Perspectives
Abstract
According to the World Health Organization (WHO), Parkinson's disease (PD) is a neurodegenerative disease of the brain that causes motor symptoms including slower movement, rigidity, tremor, and imbalance in addition to other problems like Alzheimer's disease (AD), psychiatric problems, insomnia, anxiety, and sensory abnormalities. Techniques including artificial intelligence (AI), machine learning (ML), and deep learning (DL) have been established for the classification of PD and normal controls (NC) with similar therapeutic appearances in order to address these problems and improve the diagnostic procedure for PD. In this article, we examine a literature survey of research articles published up to September 2022 in order to present an in-depth analysis of the use of datasets, various modalities, experimental setups, and architectures that have been applied in the diagnosis of subjective disease. This analysis includes a total of 217 research publications with a list of the various datasets, methodologies, and features. These findings suggest that ML/DL methods and novel biomarkers hold promising results for application in medical decision-making, leading to a more methodical and thorough detection of PD. Finally, we highlight the challenges and provide appropriate recommendations on selecting approaches that might be used for subgrouping and connection analysis with structural magnetic resonance imaging (sMRI), DaTSCAN, and single-photon emission computerized tomography (SPECT) data for future Parkinson's research.
Keywords: MRI; Parkinson’s disease; artificial neural network; deep learning; diagnosis; machine learning.
Conflict of interest statement
The authors declare no conflict of interest.
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References
-
- Arias-Vergara T., Vásquez-Correa J.C., Orozco-Arroyave J.R. Parkinson’s Disease and Aging: Analysis of Their Effect in Phonation and Articulation of Speech. Cogn. Comput. 2017;9:731–748. doi: 10.1007/s12559-017-9497-x. - DOI
-
- De Rijk M.D., Launer L.J., Berger K., Breteler M.M., Dartigues J.F., Baldereschi M., Fratiglioni L., Lobo A., Martinez-Lage J., Trenkwalder C., et al. Prevalence of Parkinson’s disease in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. Neurology. 2000;54((Suppl. 5)):S21–S23. - PubMed
-
- Cantürk İ., Karabiber F. A machine learning system for the diagnosis of Parkinson’s disease from speech signals and its application to multiple speech signal types. Arab. J. Sci. Eng. 2016;41:5049–5059. doi: 10.1007/s13369-016-2206-3. - DOI
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