Impact of Recombinant Bovine Somatotropin on Bovine Milk Composition and Fatty Acidome: A Multidose Longitudinal Study

Abstract

Somatotropin is a species-specific polypeptide hormone produced in the pituitary gland of vertebrates. When administered exogenously to cattle, it can increase milk yield. However, the trade and administration of recombinant bovine somatotropin (rbST) to farm animals have been banned in the European Union (EU). Aside from food safety issues, very little is known about the effects of this hormone on milk composition and quality. In this work, a wide profile of fatty acids (the so-called fatty acidome) was determined by GC-FID in raw milk collected from control and rbST-treated lactating cows in a multidose longitudinal study. Milk composition (lactose, protein, fat, dry matter), including minerals (Ca, K, Mg, Na, P), was also determined, and milk yield was recorded. A tendency toward a less saturated profile was observed in the milk collected from animals treated with rbST, with higher concentrations of monounsaturated fatty acids. In addition, less calcium and potassium and more lactose and protein content were observed in milk from treated animals than in regular milk. As a result of this multicomponent profiling of milk, a clear impact of somatotropin treatment on milk quality was observed. The obtained results should be particularly interesting for those countries that permit the use of this hormone in dairy production.

Keywords: bovine; composition; fatty acid; milk; minerals; quality; rbST; somatotropin.

Figure 1

Evolution of various fatty acids (% w/w of total fatty acids) and quality indexes in milk from control and recombinant bovine somatotropin (rdST)cows presented over the course of 32 weeks of study (12 rbST biweekly doses).

Figure 2

Principal component analysis scatter plot of the fatty acidome of bovine milk showing samples collected from control and recombinant bovine somatotropin animals at different time points during an experimental period of 240 days.