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Case Reports
. 2022 Oct 23;13(11):1926.
doi: 10.3390/genes13111926.

Dyslexia and Attention Deficit Hyperactivity Disorder Associated to a De Novo 1p34.3 Microdeletion

Ornella Galesi  1 , Francesco Domenico Di Blasi  2 , Lucia Grillo  1 , Flaviana Elia  2 , Maria Concetta Giambirtone  1 , Maria Grazia Figura  3 , Biagio Rizzo  4 , Serafino Buono  2 , Corrado Romano  5   6
Affiliations
Case Reports

Dyslexia and Attention Deficit Hyperactivity Disorder Associated to a De Novo 1p34.3 Microdeletion

Ornella Galesi et al. Genes (Basel). .

Abstract

The authors report on a boy with dyslexia and attention deficit hyperactivity disorder. A protocol of standardized tests assessed the neuroadaptive profile, allowing deep neuropsychiatric phenotyping. In addition to the diagnosis of dyslexia and attention deficit hyperactivity disorder, such methodology led to endeavor cognitive, adaptive, and academic skills. Chromosomal microarray analysis detected a 452.4 Kb de novo heterozygous microdeletion in chromosomal region 1p34.3, including seven OMIM genes. The authors took a thorough evaluation of the association to the phenotype of the deleted genes. Further reports could strengthen such association.

Keywords: 1p34.3 microdeletion; AGO1 gene; KIAA0319L gene; attention deficit hyperactivity disorder; dyslexia.

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Conflict of interest statement

The authors declare the absence of any conflict of interests.

Figures

Figure 1
Figure 1
Array-CGH profile of chromosome 1 of our patient.
See this image and copyright information in PMC

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