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. 2022 Oct 31;9(11):1679.
doi: 10.3390/children9111679.

Psychopathological Risk Assessment in Children with Hyperphenylalaninemia

Maria Cristina Risoleo  1   2 , Margherita Siciliano  2   3 , Luigi Vetri  4 , Ilaria Bitetti  2 , Anna Di Sessa  5 , Marco Carotenuto  2 , Francesca Annunziata  2 , Daniela Concolino  1 , Rosa Marotta  1
Affiliations

Psychopathological Risk Assessment in Children with Hyperphenylalaninemia

Maria Cristina Risoleo et al. Children (Basel). .

Abstract

Background: Phenylketonuria (PKU) is a rare congenital disorder caused by decreased metabolism of phenylalanine determining cerebral impairments. If untreated, PKU might lead to intellectual disability, seizures and behavioral disorders. The aim of this study is to provide a characterization of the psychopathological profile of a pediatric population diagnosed with PKU at newborn screening.

Methods: an accurate neuropsychological evaluation of 23 patients (aged 8-18 years) with hyperphenylalaninemia (defined as experimental group, EG) and in 23 age-matched healthy controls (defined as control group, CG) was performed using the Child and Adolescent Behavior Inventory (CABI) and Self-Administrated Psychiatric Scales for Children and Adolescents (SAFA) questionnaires.

Results: the CABI test showed significant differences for the sub-scales related to "Irritable mood", "Oppositional-provocative symptoms" and "ADHD" in the EG compared to CG (p = 0.014, p = 0.032, and p = 0.032, respectively). Patients with hyperphenylalaninemia also presented with significant differences both for anxiety disorder scale and depression scale of SAFA test than controls (p = 0.018 and p = 0.009, respectively).

Conclusions: children and adolescents with early diagnosis of PKU showed a psychopathological risk profile characterized by an increased risk of experiencing symptoms such as mood deflection, anxiety, attention deficit, oppositional defiant behavior, and obsessive traits than healthy peers. Our findings highlighted the need of the inclusion of a neuropsychiatric evaluation in the management of these patients to improve their overall quality of life.

Keywords: CABI; SAFA; neuropsychiatric disorders; phenylketonuria; psychopathological risk.

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Conflict of interest statement

Marco Carotenuto is Guest Editors of Special Issue “Special Issue “New Diagnostic and Therapeutic Perspectives in Pediatric Neurology”” of Children. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Figure 1
Figure 1
Number of subjects showing results above the cut-off in the CABI sub-scales in the EG and CG.
Figure 2
Figure 2
Number of subjects showing borderline or pathological scores in the SAFA scales in the EG and CG.
See this image and copyright information in PMC

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