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Meta-Analysis
. 2022 Oct 24;19(21):13823.
doi: 10.3390/ijerph192113823.

Effectiveness and Cost-Effectiveness of Case Management in Advanced Heart Failure Patients Attended in Primary Care: A Systematic Review and Meta-Analysis

Caterina Checa  1   2   3 , Carlos Canelo-Aybar  4 , Stefanie Suclupe  5 , David Ginesta-López  3 , Anna Berenguera  1   2 , Xavier Castells  1   6 , Carlos Brotons  7 , Margarita Posso  6
Affiliations
Meta-Analysis

Effectiveness and Cost-Effectiveness of Case Management in Advanced Heart Failure Patients Attended in Primary Care: A Systematic Review and Meta-Analysis

Caterina Checa et al. Int J Environ Res Public Health. .

Abstract

Aims: Nurse-led case management (CM) may improve quality of life (QoL) for advanced heart failure (HF) patients. No systematic review (SR), however, has summarized its effectiveness/cost-effectiveness. We aimed to evaluate the effect of such programs in primary care settings in advanced HF patients. We examined and summarized evidence on QoL, mortality, hospitalization, self-care, and cost-effectiveness.

Methods and results: The MEDLINE, CINAHL, Embase, Clinical Trials, WHO, Registry of International Clinical Trials, and Central Cochrane were searched up to March 2022. The Consensus Health Economic Criteria instrument to assess risk-of-bias in economic evaluations, Cochrane risk-of-bias 2 for clinical trials, and an adaptation of Robins-I for quasi-experimental and cohort studies were employed. Results from nurse-led CM programs did not reduce mortality (RR 0.78, 95% CI 0.53 to 1.15; participants = 1345; studies = 6; I2 = 47%). They decreased HF hospitalizations (HR 0.79, 95% CI 0.68 to 0.91; participants = 1989; studies = 8; I2 = 0%) and all-cause ones (HR 0.73, 95% CI 0.60 to 0.89; participants = 1012; studies = 5; I2 = 36%). QoL improved in medium-term follow-up (SMD 0.18, 95% CI 0.05 to 0.32; participants = 1228; studies = 8; I2 = 28%), and self-care was not statistically significant improved (SMD 0.66, 95% CI -0.84 to 2.17; participants = 450; studies = 3; I2 = 97%). A wide variety of costs ranging from USD 4975 to EUR 27,538 was observed. The intervention was cost-effective at ≤EUR 60,000/QALY.

Conclusions: Nurse-led CM reduces all-cause hospital admissions and HF hospitalizations but not all-cause mortality. QoL improved at medium-term follow-up. Such programs could be cost-effective in high-income countries.

Keywords: advanced heart failure; case management; cost-effectiveness; hospital admissions; meta-analyses; mortality; quality of life; self-care.

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Conflict of interest statement

The authors have declared that no competing interests exist. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Figures

Figure 1
Figure 1
Study flow chart of studies evaluating clinical efficacy.
Figure 2
Figure 2
Metanalysis for all-cause mortality, hospitalizations for heart failure, all-cause hospitalizations, quality of life, and self-care. CM: nurse-led case management.
Figure 2
Figure 2
Metanalysis for all-cause mortality, hospitalizations for heart failure, all-cause hospitalizations, quality of life, and self-care. CM: nurse-led case management.
See this image and copyright information in PMC

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