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Observational Study
. 2022 Nov 1;19(21):14295.
doi: 10.3390/ijerph192114295.

Is HIV Pre-Exposure Prophylaxis among Men Who Have Sex with Men Effective in a Real-World Setting? Experience with One-On-One Counseling and Support in a Sexual Health Center in Paris, 2018-2020

Bérenger Thomas  1 , Prescillia Piron  1   2 , Elise de La Rochebrochard  3   4 , Christophe Segouin  1   2 , Pénélope Troude  1   3
Affiliations
Observational Study

Is HIV Pre-Exposure Prophylaxis among Men Who Have Sex with Men Effective in a Real-World Setting? Experience with One-On-One Counseling and Support in a Sexual Health Center in Paris, 2018-2020

Bérenger Thomas et al. Int J Environ Res Public Health. .

Abstract

HIV pre-exposure prophylaxis (PrEP) is highly effective but depends on patients' care engagement, which is often mediocre and poorly measured in real-world settings. This study aimed to assess the effectiveness of a PrEP program in a sexual health center that included accompanying measures to improve engagement. A retrospective observational study was conducted. All men who have sex with men (MSM) who initiated PrEP for the first time between 1 August 2018 and 30 June 2019 in the Fernand-Widal sexual health center, Paris, France, were included. Among the 125 MSM who initiated PrEP, the median age was 33 and most had only male partners. At initiation, 58% were considered at very high risk of HIV infection, mainly due to a history of post-exposure prophylaxis. During the first year, patients attended a median of three visits (Q1-Q3, 2-4). At 12 months, 96% (95% CI, 92.6 to 99.4) had a successful PrEP course, assessed by a novel metric. These results highlight the possibility of achieving a high PrEP success ratio among MSM in a real-world setting. The accompanying measures and one-on-one counseling by a trained counselor could explain the effectiveness of this PrEP program.

Keywords: HIV prevention; MSM; pre-exposure prophylaxis; retention in care; sexually transmitted infections.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Riddell J., Amico K.R., Mayer K.H. HIV Preexposure Prophylaxis: A Review. JAMA. 2018;319:1261–1268. doi: 10.1001/jama.2018.1917. - DOI - PubMed
    1. Costagliola D., Ghosn J., Spire B., Rojas Castro D., Béniguel L., Algarte-Génin M., Pialoux G., Pintado C., Viard J.-P., Katlama C., et al. PrEP Persistence and Associated Factors: An Analysis from the ANRS Prevenir Study. HIV Med. 2019;20:33. - PubMed
    1. Conniff J., Evensen A. Preexposure Prophylaxis (PrEP) for HIV Prevention: The Primary Care Perspective. J. Am. Board Fam. Med. 2016;29:143–151. doi: 10.3122/jabfm.2016.01.150223. - DOI - PubMed
    1. Chan P.A., Patel R.R., Mena L., Marshall B.D., Rose J., Sutten Coats C., Montgomery M.C., Tao J., Sosnowy C., Mayer K.H., et al. Long-term Retention in Pre-exposure Prophylaxis Care among Men Who Have Sex with Men and Transgender Women in the United States. J. Int. AIDS Soc. 2019;22:e25385. doi: 10.1002/jia2.25385. - DOI - PMC - PubMed
    1. Huang Y.-L.A., Tao G., Smith D.K., Hoover K.W. Persistence With Human Immunodeficiency Virus Pre-Exposure Prophylaxis in the United States, 2012–2017. Clin. Infect. Dis. 2020;72:379–385. doi: 10.1093/cid/ciaa037. - DOI - PubMed

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