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. 2022 Nov 2;19(21):14324.
doi: 10.3390/ijerph192114324.

Comparing the Therapeutic Efficacies of Lung Cancer: Network Meta-Analysis Approaches

Chuan-Hsin Chang  1 , Yue-Cune Chang  2
Affiliations

Comparing the Therapeutic Efficacies of Lung Cancer: Network Meta-Analysis Approaches

Chuan-Hsin Chang et al. Int J Environ Res Public Health. .

Abstract

Background: In recent years, reduction of nuclear power generation and the use of coal-fired power for filling the power supply gap might have increased the risk of lung cancer. This study aims to explore the most effective treatment for different stages of lung cancer patients.

Methods: We searched databases to investigate the treatment efficacy of lung cancer. The network meta-analysis was used to explore the top three effective therapeutic strategies among all collected treatment methodologies.

Results: A total of 124 studies were collected from 115 articles with 171,757 participants in total. The results of network meta-analyses showed that the best top three treatments: (1) in response rate, for advanced lung cancer were Targeted + Targeted, Chemo + Immuno, and Targeted + Other Therapy with cumulative probabilities 82.9, 80.8, and 69.3%, respectively; for non-advanced lung cancer were Chemoradio + Targeted, Chemoradi + Immuno, and Chemoradio + Other Therapy with cumulative probabilities 69.0, 67.8, and 60.7%, respectively; (2) in disease-free control rate, for advanced lung cancer were Targeted + Others, Chemo + Immuno, and Targeted + Targeted Therapy with cumulative probabilities 93.4, 91.5, and 59.4%, respectively; for non-advanced lung cancer were Chemo + Surgery, Chemoradio + Targeted, and Surgery Therapy with cumulative probabilities 80.1, 71.5, and 43.1%, respectively.

Conclusion: The therapeutic strategies with the best effectiveness will be different depending on the stage of lung cancer patients.

Keywords: air pollution; fine particulate matter (PM2.5); lung cancer; network meta-analysis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
PRISMA flow diagram.
Figure 2
Figure 2
Network map of response rate/disease-free control (all treatment groups), blue is component I, and gray is component II.
Figure 3
Figure 3
Network map of response rate/disease-free control rate (advanced stage).
Figure 4
Figure 4
Rankogram for the advanced lung cancer in response rate.
Figure 5
Figure 5
Network map of response rate/disease-free control rate (non-advanced stage).
Figure 6
Figure 6
Rankogram for the non-advanced lung cancer in response rate.
Figure 7
Figure 7
Rankogram for advanced lung cancer in disease-free control rate.
Figure 8
Figure 8
Rankogram for the non-advanced lung cancer in disease-free control rate.
See this image and copyright information in PMC

References

    1. Sung H., Ferlay J., Siegel R.L., Laversanne M., Soerjomataram I., Jemal A., Bray F. Global Cancer Statistics 2020: Globocan Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J. Clin. 2021;71:209–249. doi: 10.3322/caac.21660. - DOI - PubMed
    1. The Leading Causes of Death among People in Taiwan. [(accessed on 10 September 2021)]; Available online: https://www.mohw.gov.tw/cp-5017-61533-1.html. (In Chinese)
    1. Tseng C.H., Tsuang B.J., Chiang C.J., Ku K.C., Tseng J.S., Yang T.Y., Hsu K.H., Chen K.C., Yu S.L., Lee W.C., et al. The Relationship Between Air Pollution and Lung Cancer in Nonsmokers in Taiwan. J. Thorac. Oncol. 2019;14:784–792. doi: 10.1016/j.jtho.2018.12.033. - DOI - PubMed
    1. Russel A.T. Combustion emissions. In: Straif K.A.C., Samet J., editors. Air Pollution and Cancer. IARC Scientific Publications; Lyon, France: 2013. pp. 37–48.
    1. Chan C.C., Chio P.C., Chen S.Y. Air pollution and health in Taiwan. In: Shin D.C., editor. Hazardous Air Pollutants: Case Studies from Asia. CRC Press; Boca Raton, FL, USA: 2016. pp. 47–64.

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