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Review
. 2022 Oct 26;23(21):12935.
doi: 10.3390/ijms232112935.

Review: Influence of 25(OH)D Blood Concentration and Supplementation during Pregnancy on Preeclampsia Development and Neonatal Outcomes

Nataliia Karpova  1 , Olga Dmitrenko  1 , Ekaterina Arshinova  1 , Malik Nurbekov  1
Affiliations
Review

Review: Influence of 25(OH)D Blood Concentration and Supplementation during Pregnancy on Preeclampsia Development and Neonatal Outcomes

Nataliia Karpova et al. Int J Mol Sci. .

Abstract

Briefly, 25-hydroxyvitamin D (25(OH)D) plays an essential role in embryogenesis and the course of intra- and postnatal periods and is crucially involved in the functioning of the mother-placenta-fetus system. The low quantity of 25(OH)D during pregnancy can lead to an elevated risk for preeclampsia occurrence. Despite the numerous studies on the association of 25(OH)D deficiency and preeclampsia development, the current research on this theme is contradictory. In this review, we summarize and analyze study data on the effects of 25(OH)D deficiency and supplementation on pregnancy, labor, and fetal and neonatal outcomes.

Keywords: 1,25(OH)2D; 25(OH)D; 25-hydroxyvitamin D; diabetes; neonatal outcome; preeclampsia; pregnancy complication; vitamin D deficiency; vitamin D supplementation.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Neonatal outcomes in conditions of maternal 25(OH)D insufficiency and deficiency.
See this image and copyright information in PMC

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