Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Oct 24;11(21):6255.
doi: 10.3390/jcm11216255.

Clinical Implication of Serum Adiponectin Levels in Adult Patients with Atopic Dermatitis

Sul-Hee Lee  1 , Youin Bae  2 , Young-Lip Park  1
Affiliations

Clinical Implication of Serum Adiponectin Levels in Adult Patients with Atopic Dermatitis

Sul-Hee Lee et al. J Clin Med. .

Abstract

Atopic dermatitis (AD) is characterized by chronic, relapsing, pruritic inflammatory skin disease. Adiponectin has been reported to have anti-inflammatory effects not only on metabolic disorders but also on various inflammatory disorders. The study aimed to validate adiponectin as a potential biomarker for AD disease severity and treatment response. Seventy-five patients with AD and 28 healthy volunteers were enrolled in the study. Patient information, including Eczema Area and Severity Index (EASI) scores and pruritus numeric rating scales (NRSs), were collected. An enzyme linked immunosorbent assay (ELISA) was conducted to measure levels of serum adiponectin. Additionally, sera of patients treated with dupilumab were collected and measured at 16 and 52 weeks from baseline. Serum adiponectin levels were significantly lower in moderate and severe AD patients than in the control and mild AD patients. Serum adiponectin level was negatively correlated with the EASI score and pruritus NRS. However, no significant changes were observed according to biologic treatment for AD. Low serum adiponectin levels are associated with moderate to severe AD, suggesting a potential role for adiponectin as a biomarker for severity assessment of AD.

Keywords: adiponectin; atopic dermatitis; biomarker.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Comparison of serum adiponectin levels between (A) each atopic dermatitis group classified by severity and the control group, (B) the normal weight group (BMI < 23) and the overweight or obese group (BMI ≥ 23). AD: atopic dermatitis, BMI: Body mass index. * p < 0.01.
Figure 2
Figure 2
Correlation between serum adiponectin level and various clinical and laboratory values (A) EASI score (B) pruritus NRS (C) body mass index (D) total IgE level, and (E) blood eosinophil count (%). EASI: Eczema Area and Severity Index, NRS: numeric rating scale.
Figure 2
Figure 2
Correlation between serum adiponectin level and various clinical and laboratory values (A) EASI score (B) pruritus NRS (C) body mass index (D) total IgE level, and (E) blood eosinophil count (%). EASI: Eczema Area and Severity Index, NRS: numeric rating scale.
Figure 3
Figure 3
Changes in serum adiponectin levels in response to dupilumab treatment in the group of patients with severe atopic dermatitis.
See this image and copyright information in PMC

References

    1. Ahn J., Choi Y., Simpson E.L. Therapeutic new era for atopic dermatitis: Part 1. Biologics. Ann. Dermatol. 2021;33:1–10. doi: 10.5021/ad.2021.33.1.1. - DOI - PMC - PubMed
    1. Miniotti M., Lazzarin G., Ortoncelli M., Mastorino L., Ribero S., Leombruni P. Impact on health-related quality of life and symptoms of anxiety and depression after 32 weeks of Dupilumab treatment for moderate-to-severe atopic dermatitis. Dermatol. Ther. 2022;35:e15407. doi: 10.1111/dth.15407. - DOI - PMC - PubMed
    1. Mancini A.J., Kaulback K., Chamlin S.L. The socioeconomic impact of atopic dermatitis in the United States: A systematic review. Pediatr. Dermatol. 2008;25:1–6. doi: 10.1111/j.1525-1470.2007.00572.x. - DOI - PubMed
    1. Edslev S.M., Agner T., Andersen P.S. Skin microbiome in atopic dermatitis. Acta Derm. Venereol. 2020;100:adv00164. doi: 10.2340/00015555-3514. - DOI - PMC - PubMed
    1. Liang Y., Chang C., Lu Q. The genetics and epigenetics of atopic dermatitis-filaggrin and other polymorphisms. Clin. Rev. Allergy Immunol. 2016;51:315–328. doi: 10.1007/s12016-015-8508-5. - DOI - PubMed

LinkOut - more resources