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. 2022 Oct 27;11(21):6341.
doi: 10.3390/jcm11216341.

Impact of Obstructive Sleep Apnea Syndrome on Ventricular Remodeling after Acute Myocardial Infarction: A Proof-of-Concept Study

François Bughin  1   2 , Hélène Kovacsik  3 , Isabelle Jaussent  4 , Kamila Solecki  5 , Sylvain Aguilhon  6 , Juliette Vanoverschelde  3 , Hamid Zarqane  3 , Jacques Mercier  1 , Fares Gouzi  1 , François Roubille  6 , Yves Dauvilliers  7
Affiliations

Impact of Obstructive Sleep Apnea Syndrome on Ventricular Remodeling after Acute Myocardial Infarction: A Proof-of-Concept Study

François Bughin et al. J Clin Med. .

Abstract

Background: Obstructive sleep apnea syndrome (OSA) is common in patients with acute myocardial infarction (AMI). Whether OSA impacts on the ventricular remodeling post-AMI remains unclear. We compared cardiac ventricular remodeling in patients assessed by cardiac magnetic resonance (CMR) imaging at baseline and six months after AMI based on the presence and severity of OSA. Methods: This prospective study included 47 patients with moderate to severe AMI. They all underwent CMR at inclusion and at six months after an AMI, and a polysomnography was performed three weeks after AMI. Left and right ventricular remodeling parameters were compared between patients based on the AHI, AHI in REM and NREM sleep, oxygen desaturation index, and daytime sleepiness. Results: Of the 47 patients, 49% had moderate or severe OSA with an AHI ≥ 15/h. No differences were observed between these patients and those with an AHI < 15/h for left ventricular end-diastolic and end-systolic volumes at six months. No association was found for left and right ventricular remodeling parameters at six months or for the difference between baseline and six months with polysomnographic parameters of OSA severity, nor with daytime sleepiness. Conclusions: Although with a limited sample size, our proof-of-concept study does not report an association between OSA and ventricular remodeling in patients with AMI. These results highlight the complexity of the relationships between OSA and post-AMI morbi-mortality.

Keywords: acute myocardial infarction; obstructive sleep apnea syndrome; ventricular remodeling.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study, the collection, analyses, or interpretation of data, the writing of the manuscript, or in the decision to publish the results. F.B. has lectured at sponsored meetings for the following companies in the last five years: Loewenstein Medical, Bioprojet, and Vitalaire. He has received sponsorship support to attend academic meetings in the last five years from SOS Oxygene, Agir à dom, Bastide, and ISIS. F.R. has speaking honoraria and board engagements with Abbott, Air Liquide, Bayer, Pfizer, Astra Zeneca, Servier, Boehringer, Vifor, Novartis, and Novonordisk. Y.D. has speaking honoraria and board engagements with UCB Pharma, JAZZ, Orexia, Bioprojet, Avadel, Idorsia, and Takeda.

Figures

Figure 1
Figure 1
Flow Chart.
Figure 2
Figure 2
Differences between patients with an AHI < 15/h and patients with an AHI ≥ 15/h for: (A) six-month left ventricular end-diastolic volume (LVEDV); (B) left ventricular end-systolic volume (LVESV); (C) changes between baseline and six months in LVEDV; and (D) LVESV.
Figure 3
Figure 3
Changes between baseline and six months in LVEDV between patients with: (A) AHI-REM < 15/h and ≥15/h; (B) AHI-NREM < 15/h and ≥15/h; (C) oxygen desaturation index (ODI) < 15/h and ≥15/h; and (D) Epworth sleepiness scale (ESS) ≤ 10 and >10.
See this image and copyright information in PMC

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