Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Oct 22;12(11):1677.
doi: 10.3390/life12111677.

Nystatin Effectiveness in Oral Candidiasis Treatment: A Systematic Review & Meta-Analysis of Clinical Trials

Anamika Rai  1 , Satya Ranjan Misra  1 , Saurav Panda  2 , Grzegorz Sokolowski  3 , Lora Mishra  4 , Rupsa Das  1 , Barbara Lapinska  5
Affiliations
Review

Nystatin Effectiveness in Oral Candidiasis Treatment: A Systematic Review & Meta-Analysis of Clinical Trials

Anamika Rai et al. Life (Basel). .

Abstract

Oral candidiasis is the most common opportunistic fungal infection caused by commensal Candida species. Since there are various local and systemic predisposing factors for the disease, the treatment also varies from topical to systemic antifungal agents. Nystatin is a common antifungal agent used topically. The aim of this systematic review was to evaluate and compare the efficacy of different antifungal agents and the safety of nystatin in the treatment of oral candidiasis. Three electronic databases were searched for randomized controlled trials comparing nystatin with other anti-fungal therapies or placebo. Clinical and/or mycological cure was the outcome evaluation. A meta-analysis and descriptive study on the efficacy, treatment protocols, and safety of nystatin was also conducted. The meta-analysis included five studies, which compared the efficacy of nystatin suspensions with photodynamic therapy. A significant difference in the colony-forming units per milliliters (CFU/mL) of Candida species was observed at 60 days intervals for both palatal mucosa and denture surfaces, with both groups favoring nystatin with low heterogeneity at a 95% confidence interval. Nystatin and photodynamic therapy were found to be equally effective for the clinical remission of denture stomatitis as well as a significant reduction of CFU/mL of Candida species from dentures and palatal surfaces of the patients.

Keywords: denture stomatitis; meta-analysis; nystatin; oral candidiasis; photodynamic therapy; systematic review; treatment duration.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Study selection and PRISMA flowchart.
Figure 2
Figure 2
Depicting the plot of the distribution of review authors’ judgments across studies for each risk of bias item.
Figure 3
Figure 3
A summary table of review authors’ judgments for each risk of bias item for each study.
Figure 4
Figure 4
Forest plot comparing the efficacy of nystatin and PDT on palatal mucosa (a) and denture surface (b) in 15 days.
Figure 5
Figure 5
Forest plot comparing the efficacy of nystatin and PDT on palatal mucosa (a) and denture surface (b) in 30 to 45 days.
Figure 6
Figure 6
Forest plot comparing the efficacy of nystatin and PDT on palatal mucosa (a) and denture (b) surface in 60 days.
Figure 7
Figure 7
Forest plot comparing the efficacy of nystatin and PDT on palatal mucosa (a) and denture (b) surface in 80 to 95 days.
See this image and copyright information in PMC

References

    1. Tuganbaev T., Yoshida K., Honda K. The effects of oral microbiota on health. Science. 2022;376:934–936. doi: 10.1126/science.abn1890. - DOI - PubMed
    1. Baker J.L., Bor B., Agnello M., Shi W., He X. Ecology of the Oral Microbiome: Beyond Bacteria. Trends Microbiol. 2017;25:362–374. doi: 10.1016/j.tim.2016.12.012. - DOI - PMC - PubMed
    1. Arkell S., Shinnick A. Update on oral candidosis. Nurs. Times. 2003;99:52–53. - PubMed
    1. Millsop J.W., Fazel N. Oral candidiasis. Clin. Dermatol. 2016;34:487–494. doi: 10.1016/j.clindermatol.2016.02.022. - DOI - PubMed
    1. Sherman R.G., Prusinski L., Ravenel M.C., Joralmon R.A. Oral Candidosis. Quintessence Int. 2001;33:521–532. doi: 10.12968/denu.2001.28.3.132. - DOI - PubMed

LinkOut - more resources