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Review
. 2022 Oct 25;27(21):7222.
doi: 10.3390/molecules27217222.

Therapeutic Potential of Select Dietary Compounds in the Management of Hypertension and its Cardiovascular Complications

Aleena Francis Valookaran  1   2 , Jenny Bouchard  1   2   3   4 , Basma Milad Aloud  5 , Sijo Joseph Thandapilly  1   2   3   4 , Thomas Netticadan  1   2   6
Affiliations
Review

Therapeutic Potential of Select Dietary Compounds in the Management of Hypertension and its Cardiovascular Complications

Aleena Francis Valookaran et al. Molecules. .

Abstract

Hypertension is a common risk factor for cardiovascular disease and mortality worldwide. Proper nutrition and diet are known to play an indispensable role in the treatment and management of hypertension. Bioactive compounds that occur in small quantities in foods such as onions, fish and red wine are being intensively studied to uncover their vasoprotective, antioxidant, anti-proliferative and anti-inflammatory effects which are beneficial to attenuate chronic disease and protect human health. In this article, the anti-hypertensive, and cardio-protective effects of five food-derived bioactive compounds: resveratrol, quercetin, coenzyme Q10, DHA and EPA and their proposed mechanisms of action are reviewed in detail.

Keywords: bioactive compounds; coenzyme Q10; docosahexaenoic acid; eicosapentaenoic acid; hypertension; quercetin; resveratrol.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Most popular food sources of the bioactive compounds are resveratrol, quercetin, coenzyme Q10, EPA, DHA.
Figure 2
Figure 2
Proposed mechanisms of action of the bioactive phenolic compounds resveratrol, quercetin, and coenzyme Q10. Upward facing arrows indicate an increase in activity, while downward facing arrows indicate a decrease in activity.
Figure 3
Figure 3
Proposed mechanisms of action of EPA and DHA. Upward facing arrows indicate an increase in activity, while downward facing arrows indicate a decrease in activity.
See this image and copyright information in PMC

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