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Review
. 2022 Nov 3;14(21):4647.
doi: 10.3390/nu14214647.

Multidisciplinary Prehabilitation and Postoperative Rehabilitation for Avoiding Complications in Patients Undergoing Resection of Colon Cancer: Rationale, Design, and Methodology of the ONCOFIT Study

Francisco J Amaro-Gahete  1   2   3 , Javier Jurado  4 , Andrea Cisneros  4 , Pablo Corres  5 , Andres Marmol-Perez  1 , Francisco J Osuna-Prieto  1   6 , Manuel Fernández-Escabias  1 , Estela Salcedo  7 , Natalia Hermán-Sánchez  3   8   9   10 , Manuel D Gahete  3   8   9   10 , Virginia A Aparicio  11   12 , Cristina González-Callejas  4 , Benito Mirón Pozo  4 , Jonatan R Ruiz  1   3   13 , Teresa Nestares  11   12 , Almudena Carneiro-Barrera  1   14
Affiliations
Review

Multidisciplinary Prehabilitation and Postoperative Rehabilitation for Avoiding Complications in Patients Undergoing Resection of Colon Cancer: Rationale, Design, and Methodology of the ONCOFIT Study

Francisco J Amaro-Gahete et al. Nutrients. .

Abstract

ONCOFIT is a randomized clinical trial with a two-arm parallel design aimed at determining the influence of a multidisciplinary Prehabilitation and Postoperative Program (PPP) on post-surgery complications in patients undergoing resection of colon cancer. This intervention will include supervised physical exercise, dietary behavior change, and psychological support comparing its influence to the standard care. Primary and secondary endpoints will be assessed at baseline, at preoperative conditions, at the end of the PPP intervention (after 12 weeks) and 1-year post-surgery, and will include: post-surgery complications (primary endpoint); prolonged hospital length of stay; readmissions and emergency department call within 1-year after surgery; functional capacity; patient reported outcome measures targeted; anthropometry and body composition; clinical/tumor parameters; physical activity levels and sedentariness; dietary habits; other unhealthy habits; sleep quality; and fecal microbiota diversity and composition. Considering the feasibility of the present intervention in a real-life scenario, ONCOFIT will contribute to the standardization of a cost-effective strategy for preventing and improving health-related consequences in patients undergoing resection of colon cancer with an important clinical and economic impact, not only in the scientific community, but also in clinical practice.

Keywords: cardiovascular risk factors; exercise; nutrition; oncology; public health; tumor.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram of the ONCOFIT study patients.
Figure 2
Figure 2
Training periodization of the ONCOFIT study. Abbreviations: HIIT; High Intensity Interval Training, pHR; peak Heart Rate, RPE; Rating Perceived Exertion.
Figure 3
Figure 3
Structure of the implemented concurrent training session within the prehabilitation and postoperative phase. Abbreviations: HIIT; High Intensity Interval Training.
See this image and copyright information in PMC

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