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. 2022 Oct 31;14(11):2425.
doi: 10.3390/v14112425.

Cytomegalovirus Specific Serological and Molecular Markers in a Series of Pregnant Women With Cytomegalovirus Non Primary Infection

Claire Périllaud-Dubois  1   2 , Emmanuelle Letamendia  3 , Elise Bouthry  4 , Rana Rafek  5 , Isabelle Thouard  5 , Corinne Vieux-Combe  5 , Olivier Picone  1   6 , Anne-Gaël Cordier  7 , Christelle Vauloup-Fellous  5   8
Affiliations

Cytomegalovirus Specific Serological and Molecular Markers in a Series of Pregnant Women With Cytomegalovirus Non Primary Infection

Claire Périllaud-Dubois et al. Viruses. .

Abstract

(1) Background: In a period where systematic screening of CMV during pregnancy is still debated, diagnosis of non primary infection (NPI) remains challenging and an obstacle to systematic screening. Our aim is to report kinetics of serological and molecular CMV markers of NPI. (2) Methods: We identified immunocompetent pregnant women with CMV NPI as women known to be seropositive for CMV before pregnancy who gave birth to cCMV infected infants. We performed CMV-IgG, CMV-IgM, CMV-IgG avidity and CMV PCR retrospectively on sequential serum samples collected during pregnancy. (3) Results: We collected 195 serum samples from 53 pregnant women with NPI during pregnancy. For 29/53 (55%) patients, no markers of active infection were observed (stable IgG titers, negative IgM and negative PCR). CMV PCR was positive in at least one serum for 18/53 (34%) patients and median viral load was 46 copies/mL, IQR (21-65). (4) Conclusions: For more than half of patients with confirmed CMV NPI during pregnancy, available diagnostic tools are liable to fail in detecting an active infection. These should therefore not be used and universal neonatal screening for CMV remains the only way to detect all cCMV infections.

Keywords: CMV PCR; CMV non primary infection; cCMV; pregnant women; serology; serum.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Kenneson A., Cannon M.J. Review and Meta-Analysis of the Epidemiology of Congenital Cytomegalovirus (CMV) Infection. Rev. Med. Virol. 2007;17:253–276. doi: 10.1002/rmv.535. - DOI - PubMed
    1. Dollard S.C., Grosse S.D., Ross D.S. New Estimates of the Prevalence of Neurological and Sensory Sequelae and Mortality Associated with Congenital Cytomegalovirus Infection. Rev. Med. Virol. 2007;17:355–363. doi: 10.1002/rmv.544. - DOI - PubMed
    1. Stagno S., Pass R.F., Cloud G., Britt W.J., Henderson R.E., Walton P.D., Veren D.A., Page F., Alford C.A. Primary Cytomegalovirus Infection in Pregnancy. Incidence, Transmission to Fetus, and Clinical Outcome. JAMA. 1986;256:1904–1908. doi: 10.1001/jama.1986.03380140074025. - DOI - PubMed
    1. Picone O., Vauloup-Fellous C., Cordier A.G., Guitton S., Senat M.V., Fuchs F., Ayoubi J.M., Grangeot Keros L., Benachi A. A Series of 238 Cytomegalovirus Primary Infections during Pregnancy: Description and Outcome: Outcome of Maternal CMV Infection during Pregnancy. Prenat. Diagn. 2013;33:751–758. doi: 10.1002/pd.4118. - DOI - PubMed
    1. Chatzakis C., Ville Y., Makrydimas G., Dinas K., Zavlanos A., Sotiriadis A. Timing of Primary Maternal Cytomegalovirus Infection and Rates of Vertical Transmission and Fetal Consequences. Am. J. Obstet. Gynecol. 2020;223:870–883. doi: 10.1016/j.ajog.2020.05.038. - DOI - PubMed