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. 2023 Apr;21(2):266-269.
doi: 10.5217/ir.2022.00112. Epub 2022 Nov 14.

Anti-inflammatory properties of butyrate-producing atypical Escherichia coli in a murine colitis model

Ji Hyung Kim  1   2 , Jee In Yoo  3 , Hyun Woo Ma  1   2 , I Seul Park  1   2 , Mijeong Son  1   2 , Yoojin Shin  1   2 , Ki Beom Kim  1   2 , Seung Won Kim  1   2   4 , Si Jae Park  3 , Jihye Park  1
Affiliations

Anti-inflammatory properties of butyrate-producing atypical Escherichia coli in a murine colitis model

Ji Hyung Kim et al. Intest Res. 2023 Apr.
No abstract available

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Conflict of interest statement

Conflict of Interest

Park J is an editorial board member of the journal but was not involved in the peer reviewer selection, evaluation, or decision process of this article. No other potential conflicts of interest relevant to this article were reported.

Figures

Fig. 1.
Fig. 1.
Anti-inflammatory effects of butyrate-producing atypical Escherichia coli in murine DSS colitis model. (A) Scheme of the experiment. Eight-week-old male C57BL/6 mice were treated 1×108 bacteria or PBS daily by oral gavage. (B) Body weight was checked during the 12 days before and after induction of colitis by 2.5% DSS added to the drinking water from day 3 of gavage and continued for 7 days. All mice were euthanized on day 12 of the study and disease activity index (C), colon length (D), periodic acid-Schiff staining (E), histopathological score (F), and survival rates (G) were analyzed. Data are expressed as the mean±standard error of the mean (n=4). Analyses were performed using two-way analysis of variance (ANOVA) followed by Tukey multiple comparison test (B, C) and one-way ANOVA followed by Holm-Sidak multiple comparison test (D, F). avs. control: P<0.001, b-dvs. DSS+PBS group or between indicated groups: bP<0.05, cP<0.01, cP<0.001. PBS, phosphate buffered saline-treated vehicle; DSS, dextran sulfate sodium treated; atEc, atypical E. coli-treated; butyrate atEc, butyrate atypical E. coli-treated.
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